Is there anything either already in the medical arsenal, or in the pipeline, that could be used instead of opioids? If not, why not? If the problem of chronic pain is so significant, it ought to be worth the while of drug companies to produce materials to address it.

If there is nothing else and no one is interested, what is the alternative? The current choices would appear to be analgesia through opioids that is of questionable effectivness, or no analgesia at all.