We don't know for sure yet how much is permanent vs reversible, it probably depends on what age you started. That said, I've seen dramatic changes in young adults who quit, suggesting that the brain is healing. So my best guess is that a significant portion is reversible, especially with sustained abstinence.

Try quitting for 4 weeks as an experiment and see what changes you see in terms of your focus, mood, anxiety, sleep, interests, ability to relate to others, etc.

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