This 'article' contains logical fallacies and incorrect information. Please see wikipedia for more info on endocannabinoids their production and function in humans & mammals. From "...This system, an integral part of our physiologies, was discovered in the mid-1990s by Israeli researcher Dr. Ralph Mechoulam who also identified THC as the main active ingredient in cannabis in the early 1960s. Israel has been one of the most progressive nations for cannabis research and currently has one of the most advanced medical marijuana programs in the world...Dr. Mechoulam’s world-changing research discovered two main receptors, cannabinoid 1 (CB1) and cannabinoid 2 (CB2), that are keyed to both the endocannabinoids that our body naturally produces and phytocannabinoids (plant-based) like THC and CBD. Our bodies actually produce the ECsCB1 receptors are primarily found in the brain...Current research shows that THC is specifically keyed to the CB1 site. Therefore it is responsible for the feeling of intoxication that is the most familiar aspect of cannabis. From a therapeutic standpoint, it’s most important effect is to modulate and moderate the perception of pain.
THC moderates pain; this doesn’t mean we leave our finger on the stove, but that the intensity of the painful feeling is reduced when THC is present in the CB1 site. This mechanism of action is why THC-rich medicines are so prized by people with intense pain issues... Additionally, CB1 receptors are not present in the part of the brain that regulates heart rate and respiration, so unlike narcotics, there is no lethal dosage threshold for THC, allowing someone to consume as much is needed for its palliative effects. CB2 receptors are primarily found in the immune system with the highest concentration located in the spleen. There is some evidence that the receptors might also be in the of the brain...The CB2 receptors are keyed to CBD and works as an anti-inflammatory agent. The immune-boosting functions of CB2 are far less understood as research into CBD is just really beginning. It’s only been about five years since CBD re-emerged in the medical cannabis scene and was identified through Steephill Labs. The benefits of CBD-rich medicine, with its anti-spasmodic qualities, is one the most exciting and promising areas of cannabis medical research... One of the other effects of CBD is that it moderates the effects of THC. It actually knocks THC off the CB1 receptor, so if someone is experiencing THC intoxication, a strong dose of CBD can counteract those effects. The future of CBD-rich medicines is almost limitless...The fact that there is a system in our body that produces cannabinoids, and is specifically designed to accept just them, should be overwhelming proof of cannabis’ efficacy as a medicine. From the pain-killing effects of THC to the anti-spasmodic and anti-inflammatory properties of CBD, we have just scratched the surface of a world of possibilities. "
Again "...CB1 receptors are not present in the part of the brain that regulates heart rate and respiration, so unlike narcotics, there is no lethal dosage threshold for THC..." quoted from
I would need to see the article(s) this author referenced. Statements he makes are not footnoted to enable a reader to check the truth of his claims. The info in the above article seems to show correlation and not cause and effect. As you can see from the accounts above in the comments section many folk (including cancer, epilepsy patients, etc) who smoke pot daily are educated and professional people who work productively, long and hard, and many hours including exercise, taking care of family and hobbies. He also wrote that "Any exogenous substance, like cannabis, hijacks the pre-existing receptors for the endogenously produced neurochemical. Contrary to popuar belief, endocannabinoids are more strongly linked to ‘runner’s high’ than endorphins." First of all not just any exogenous substances (external chemicals) have the chemical ability to plug into the endocannabinoid receptors. However one exogenous substance that can (the only one I'm aware of, but again no footnotes-can't check) is natural cannabinoids found in pot plants because it has the correct chemical structure to fit. He goes on to state that endocannabinoids (apparently from some unnamed source) are more LINKED to runner's high. This appears to contradict his claim that people who have cannabinoids in their bodies (even those that are naturally produced by our bodies I have to assume) are unmotivated. How are these unmotivated people able to be runners? It takes a lot of energy and determination to be a runner. These are some of the difficulties I have found in reading this article.