The new research in BPD tends to indicate an Opioid system disfunction as the cause for many of the BPD "symptoms".

The sensitivity of opioid receptors or the availability of endogenous opioids constitute part of the underlying pathophysiology of BPD. The alarming symptoms and self-destructive behaviors of the affected patients may be explained by uncontrollable and unconscious attempts to stimulate their endogenous opioid system (EOS) and the dopaminergic reward system, regardless of the possible harmful consequences. Neurobiological findings that support this hypothesis are reviewed: Frantic efforts to avoid abandonment, frequent and risky sexual contacts, and attention-seeking behavior may be explained by attempts to make use of the rewarding effects of human attachment mediated by the EOS. Anhedonia and feelings of emptiness may be an expression of reduced activity of the EOS. Patients with BPD tend to abuse substances that target mu-opioid receptors. Self-injury, food restriction, aggressive behavior, and sensation seeking may be interpreted as desperate attempts to artificially set the body to survival mode in order to mobilize the last reserves of the EOS. BPD-associated symptoms, such as substance abuse, anorexia, self-injury, depersonalization, and sexual overstimulation, can be treated successfully with opioid receptor antagonists. An understanding of the neurobiology of BPD may help in developing new treatments for patients with this severe disorder.

They tend to harm themselves to soothe themselves and increase opioids. (Harming another person does not elicit this Opioid boost).

Most BPD's that I have ever met are desperately wanting approval from others,.They are more "other approval centered" than "self approval centered" ie desperately wanting someone else to validate them rather than just validating themselves. They don't hate others inherently instead they hate themselves.

They are completely different from the Sociopathy of most serial killers even if they are "cluster B"

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