Consciousness
Can an Organ Transplant Change Your Personality?
An update on the science and stories of cellular memory.
Posted January 18, 2025 Reviewed by Lybi Ma
Key points
- Personality and identity changes are often described following an organ transplant.
- The recipients' personality changes sometimes match the personality traits of their donors.
- Cellular memory may help explain the personality changes described by transplant recipients.
- Mechanisms of cellular memory include molecular, epigenetic, RNA, neurological, biochemical, and water memory.

Organ transplantation is often heralded as a miraculous medical advancement, offering individuals with failing organs a second chance at life. However, alongside the physical and medical challenges of transplantation, intriguing reports have surfaced about changes in personality and identity following the procedure. These accounts, sometimes attributed to "cellular memory,” have sparked curiosity and debate in scientific and lay communities. Is it possible that getting a new organ could change your personality?
The Concept of Personality Changes Post-Transplant
Personality encompasses a person’s enduring patterns of thinking, feeling, and behaving. Post-transplant personality changes have been reported anecdotally and in observational studies by both recipients and their families. These changes range from subtle shifts in preferences and behaviors to profound alterations in identity. Recipients have described acquiring new tastes, hobbies, or even memories that seemingly reflect aspects of their organ donors. This phenomenon has intrigued researchers and sparked hypotheses about the mechanisms potentially driving these changes.
Anecdotal Evidence: Real-Life Accounts
Some of the most striking evidence for personality changes comes from personal stories. These stories include cases where recipients reported unexpected shifts in their preferences, habits, or memories.
- A 5-year-old boy received the heart of a 3-year-old. The recipient said “I gave the boy a name. I call him Timmy. He got hurt bad when he fell down. He likes Power Rangers a lot I think, just like I used to. I don’t like them anymore though.” The donor’s name was Thomas, but his family called him “Tim,” and he died when he fell trying to reach a Power Ranger toy that had fallen on the ledge of a window.
- A 17-year-old black male was the victim of a drive-by shooting. The recipient of his heart was a 47-year-old white male foundry worker. The recipient’s wife said: “He’s driving me nuts with the classical music. He doesn’t know the name of one song and never, never listened to it before. Now he sits for hours and listens to it. He even whistles classical music songs that he could never know.” The mother’s donor reported “Our son was walking to violin class when he was hit. Nobody knows where the bullet came from, but it just hit him, and he fell. He died right there on the street hugging his violin case.”
- In her book A Change of Heart, Claire Sylvia, a heart-lung transplant recipient, described developing a sudden craving for chicken nuggets and beer, foods she later learned were favorites of her young male donor.
- A 34-year-old police officer was shot in the face while attempting to arrest a drug dealer. The recipient, a 56-year-old college professor, reported the only side effect of his transplant surgery was seeing flashes of light in his face.
Such reports raise questions about the potential for organs to carry physiological functions and psychological or experiential imprints.
The Science Behind Cellular Memory
One hypothesis proposed to explain such personality changes is the concept of cellular memory, which suggests donor organs may retain some form of memory or information encoded in their cells. While the idea may sound far-fetched, numerous biological mechanisms exist that could plausibly contribute to such phenomena.

- Molecular Encoding: Cells use molecular pathways to encode and store information. For example, proteins and enzymes involved in cellular signaling can carry "imprints" of past interactions or states, which may influence cellular behavior when transplanted into a new body.
- Epigenetic Modifications: Epigenetic markers such as DNA methylation and histone acetylation serve as a form of "memory" within the cell. These markers can affect gene expression patterns and potentially transfer donor-specific traits to the recipient.
- RNA Transfer: Non-coding RNAs, such as microRNAs, can carry regulatory information between cells. This mechanism could allow donor cells to influence recipient cells by altering their genetic or metabolic activity.
- Neuronal-Like Functions: Certain cell types, such as cardiomyocytes and enteric neurons, have properties similar to brain neurons, including the ability to store and transmit signals. This suggests that transplanted organs containing these cells might contribute to behavioral or psychological changes.
- Immune System Interactions: The immune system itself has memory capabilities. Donor cells may interact with the recipient’s immune cells in ways that influence behavior or perception, particularly if the donor’s cells carry information about their original host’s experiences or preferences.
- Biochemical Resonance: Cells might communicate through subtle biochemical or electromagnetic signals, influencing nearby cells in ways that contribute to systemic changes in the recipient.
- Water Memory: Nobel Prize-winning scientist Luc Montagnier has demonstrated that water has the ability to encode and store information. This suggests that water in transplanted organs might transfer information from donors to recipients.
Ethical Implications
The idea that donor organs may influence personality raises several ethical questions. For example, should donors or their families be informed about the potential for personality changes? Should this information be disclosed to recipients? If personality changes align with donor traits, could this inadvertently reveal private details about the donor? Recipients experiencing identity shifts may require psychological support to navigate these changes. Integrating mental health services into post-transplant care may help recipients better accept and integrate their new organ.
Future Directions in Research
More rigorous research is needed to explore the phenomenon of personality changes post-transplant. Some recommendations include:
- Prospective studies examining personality before and after transplant could shed light on possible changes resulting from transplant surgery.
- Studies with more participants could provide more robust data.
- Advanced techniques in genetics, epigenetics, and neuroscience could shed light on potential mechanisms of cellular memory.
- Tracking recipients over time could help distinguish temporary psychological effects from long-term changes.
- Collaboration between psychologists, neurologists, and transplant specialists is essential to gain a holistic understanding of the phenomenon.
Conclusion
The idea of personality changes following organ transplantation is both fascinating and controversial. While anecdotal reports and observational studies suggest such changes may occur, more scientific investigation is needed. The evidence for cellular memory is compelling and further studies will likely shine light on the multitudinous ways that cells can encode and store information.
As research continues, understanding post-transplant personality changes could enhance the quality of care for transplant recipients, addressing not only their physical health but also their psychological well-being. Regardless of the mechanisms involved, the phenomenon of post-transplant personality changes invites us to reconsider the intricate connections between mind, body, and identity.
References
Carter, B., Khoshnaw, L., Simmons, M., Hines, L., Wolfe, B., & Liester, M. (2024). Personality Changes Associated with Organ Transplants. Transplantology, 5(1), 12-26.
Sylvia, C. (1997). A Change of Heart: A Memoir. Little, Brown, and Company.
Pearsall, P. (1998). The Heart’s Code: Tapping the Wisdom and Power of Our Heart Energy. Broadway Books.
Pearsall, P., Schwartz, G. E., & Russek, L. G. (2000). Changes in heart transplant recipients that parallel the personalities of their donors. Integrative Medicine, 2(2-3), 65-72.
Flores, A. I., & Liester, M. B. (2024). The Role of Cells in Encoding and Storing Information: A Narrative Review of Cellular Memory. Cureus, 16(11), e73063.