Resilience
The 5 Most Science-Backed Nootropics for Energy
Citicoline, Rhodiola Rosea, Caffeine, Acetyl-L-Carnitine, and Curcumin
Posted December 26, 2019 Reviewed by Kaja Perina
THE BASICS

Optimal energy undergirds motivation, and allows one to carry out cognitive or physical tasks.
A nootropic is a substance that, if used properly, safely enhances the cognitive functions of the user.
Out of the 178 human placebo-controlled studies with 7619 experimental group participants on 77 nootropics we've reviewed for our app, 16 nootropics had a significant improvement on energy in 29 human placebo-controlled studies with a total of 701 experimental group participants.
The nootropics with the most scientific evidence backing their efficacy and safety for energy are:
Best: Citicoline
2nd: Rhodiola Rosea
3rd: Caffeine
4th: Acetyl-L-Carnitine
5th: Curcumin
Citicoline
We have reviewed 8 human placebo-controlled studies on Citicoline, in which 493 participants received the nootropic.
Citicoline is a choline source with potential to improve:
- Short-term memory
- Learning
- Mindfulness
- Problem-solving
- Attention
- Energy
- Long-term memory
- Neuroprotection
Significantly more frequent side effects than in the placebo groups of the studies: None.
Usage
Frequency: Daily, or as-needed
Form of consumption: Citicoline (a.k.a. CDP-choline) capsules or powder
Time of day: Before noon
Amount: Light = 50 mg. Common = 100 mg. Strong = 300 mg.
A pronounced effect usually comes on after 30–60 minutes, lasts for 12 hours, and is normally followed by 6 hours of after effects.
Rhodiola Rosea
We have reviewed 4 human placebo-controlled studies on Rhodiola Rosea, in which 202 participants received the nootropic.
Rhodiola Rosea is an adaptogenic herb that has the potential to improve:
- Mood
- Sleep
- Anxiety
- Energy
- Short-term memory
- Creativity
- Problem-solving
Significantly more frequent side effects than in the placebo groups of the studies: None.
Usage
Frequency: Daily, or as-needed
Form of consumption: Root extract (our dosages regard this powder), tincture, whole root powder
Time of day: User’s choice
Amount: Light = 50 mg. Common = 500 mg. Strong = 1000 mg.
A pronounced effect usually comes on after 60 minutes, lasts for 20 hours, and is normally followed by 10 hours of after effects.
Caffeine
We have reviewed 4 human placebo-controlled studies on Caffeine, in which 196 participants received the nootropic.
Caffeine is a stimulant that has the potential to improve:
- Short-term memory
- Problem-solving
- Attention
- Energy
- Mood
- Sociality
Significantly more frequent side effects than in the placebo groups of the studies: None.
Usage
Frequency: As-needed
Form of consumption: Pill, powder, coffee, tea
Time of day: Before noon
THE BASICS
Amount: Light = 50 mg. Common = 120mg. Strong = 700 mg.
A pronounced effect usually comes on after 30–60 minutes, lasts for 6 hours, and is normally followed by 6 hours of after effects.
Acetyl-L-Carnitine
We have reviewed 10 human placebo-controlled studies on Acetyl-L-Carnitine, in which 377 participants received the nootropic.
Acetyl-L-Carnitine is an amino acid with potential to improve:
- Energy
- Problem-solving
- Short-term memory
- Long-term memory
- Attention
- Verbal fluency
- Creativity
- Learning
- Sociality
- Mood
- Anxiety
- Sleep
Significantly more frequent side effects than in the placebo groups of the studies: None.
Usage
Frequency: Daily, or as-needed
Resilience Essential Reads
Form of consumption: Acetyl-L-Carnitine (our dosages regard this powder), L-carnitine
Time of day: User’s choice
Amount: Light = 100 mg. Common = 500 mg. Strong = 2,000 mg.
A pronounced effect usually comes on after 30–60 minutes, lasts for 12 hours, and is normally followed by 6 hours of after effects.
Curcumin
We have reviewed 6 human placebo-controlled studies on Curcumin, in which 216 participants received the nootropic.
Curcumin is a polyphenol found in the spice turmeric with potential to improve:
- Mood
- Anxiety
- Energy
- Short-term memory
- Problem-solving
Significantly more frequent side effects than in the placebo groups of the studies: None.
Usage
Frequency: Daily, or as-needed
Form of consumption: Powder with piperine (our dosages regard this powder), powder, capsules
Time of day: User’s choice
Amount: Light = 200 mg. Common = 400 mg. Strong = 1000 mg.
A pronounced effect usually comes on after 60 minutes, lasts for 24 hours, and is normally followed by 24 hours of after effects.
Conclusion
If you have the right mindset to nootropics use (awareness of risks and how to avoid them), you’re in a great position for experience engineering success.
To start experimenting with nootropics, you can use our app to get a nootropic recommendation for your specific goals.
To achieve peak cognitive performance and well-being, make sure to upgrade your sleep, exercise, nutrition, and mindfulness.
Are you taking any other drugs or nootropics? Find interactions here.
This blog post was originally published at nootralize.com, it is not a substitute for professional medical advice, diagnosis or treatment.