Eugene Rubin, M.D., Ph.D.

Eugene Rubin, M.D., Ph.D.

Eugene Rubin, M.D., Ph.D., is Professor and Vice-Chair for Education in the Department of Psychiatry at Washington University in St. Louis - School of Medicine.  He is also Professor of Psychology at Washington University in St. Louis.  He is a clinical investigator in the Washington University Alzheimer's Disease Research Center, and he is involved in clinical research studying depression in the context of co-morbid medical illness.  He was the director of the psychiatry residency training program at Washington University in St. Louis School of Medicine from 1987-2007. He has authored or co-authored approximately 125 publications, including 75 in peer-reviewed journals.  He and Dr. Charles Zorumski recently published a book for the general public entitled Demystifying Psychiatry: A Resource for Patients and Families.

Question on genes and bipolar disorder/shizophrenia

I have a question, please on a comment on genes in the article on schizophrenia, bipolar disorder and genes. I teach middle school science, including units on genes, DNA and reproduction. So, I have a little more knowledge on this than the average person, but am not a scientist.

I was always under the impression that genes were more or less hard-wired, unless there was some mutation, or that the gene pool might gradually, incrementally, slightly change over vast periods of times, thousands of years at least.

The article states that there may be slight changes in a large pool of genes (not referring tot he exact wording bu the general idea) in persons w/ bipolar disorder or schizophrenia.

Is there actually scientific evidence for that? or is it observational or inferred? Do the genes, then, mutate? Are they weakened chemically? If the genes change, does that change in genes get passed on to offspring?

Previously, there was emphasis on genetic markers predictive for the development of a specific mental illness. The line of thinking that bipolar or schizophrenia is a combination of genes and environment is well supported. The other line of thinking, about which the questions here are asked is different, and I'm not personally aware of the evidence for that, although there might be some evidence for it, which is why I'm asking here.

These are some of the questions that come up with that line of thinking of comment. If there is any explanation or available references for that, I'd appreciate it. Thanks very much.


response to question

SGW aycnp at in case a private answer is provided.


Greetings from Malaybalay City, Bukidnon , Philippines!

I am very much delighted to read your articles. It has helped me a lot especially now that I am into volunteerism reaching out and engage into stress debriefing of victims of Sendong typhoon here in our country and other cases that will be very beneficial for the clients.

Looking forward to find linkages with you.
God bless !

Imelda Agnes Tubeo

Reply to comment | Psychology Today

Ballerine Ugg Prezzi rEvTo D'un point de vue des jours ouvrables de capitaux, jours untshanged.on le tableau des
flux de trésorerie, vous remarquerez que nous avons généré $ 169,7 millions de trésorerie et d'exploitation des activités
pour le quatrième trimestre de 2013 par rapport à $
165,5 millions pour le quatrième trimestre de 2012 les dépenses de la ville étaient $ 87,6 millions pour le quatrième trimestre de
2013 par rapport à 24,5 millions $ au quatrième trimestre de 2012 pour l'année, nous avons investi $
196,1 millions dans le capital expenditures.for 2014, nous prévoyons investir environ 200 millions de dollars en dépenses en immobilisations totales pour l'entretien, l'amélioration de
la productivité et des projets de croissance organique.
Giubbotti Moncler donna grande risvolto bottoni bianco Ugg Roma cVjnD D'autres disent que les Afro-Américains ont commencé à
quitter il ya Ouest Oakland années en raison de la criminalité et
des écoles, en laissant les postes vacants pour les nouveaux arrivants
dans ce cas, la plupart des jeunes attirés par le beau temps,
la proximité de San Francisco et le bloc après bloc de Victoriens abordables et altramadern condos.In pas cas,
West Oakland ressemble beaucoup différente de ce qu'elle
était il ya une décennie. Rivenditori Ugg Choo Ugg MqbXB Sait combien je me soucie, peu importe ce que l'enfer est-ce que dire sur moi,
je l'aime toujours. Ugg Italia Online I NEONATI HwXXv Lorsque
j'ai abordé le rôle de maître de Doris Miller dans le classique Pearl Harbor de Michael Bay, vous tous, les fans Cuba, ont contribué
à faire du film un succès au box-office.
Ugg Schweiz Moncler armoise danna giubbotti kaki vNafM A marqué le
point gagnant sur Jennifer otage de simple dans le fond de la 10e
à donner Seymour (22 1) une victoire 1 à
0 sur stonington pour le Championnat B Softball CIAC classe à Falcon Field à

Is Yout Doctor Conducting A Drug Study

I very much liked your article noted above, and hope that you will allow me to reference it in a blog post. I treat many patients with Parkinson's, and they are often confused or ambivalent about participating in a new drug trial, but, also worried that their physician might get "angry" with them if they refuse. Unfortunately, even outside of drug trials, I find patients are often prescribed medications to ameliorate some symptom ( eg: memory loss), but with no objective referent point given to the patient or spouse as to how they might even judge the pills benefit.
Mary Spremulli,MA,CCC-SLP


Dear Professor Rubin

Would you please permit me to republish your written as:" Good Psychiatrists Should..." in the web: then psychiatric residents will discuss on this topic:
"Good Psychiatrists "

Amir Hosein Jalali
Assistant Professor of Psychiatry
Tehran psychiatric institute