One Drug Makes You Fearless: The Morning-Before Pill

Go ask Alice.

What if our society comes to the point where we have nothing to fear but...an expired prescription? What if science could wipe our painful memories away, without surgery? What if there were a pill that could eliminate fear, making the individual resistant to his or her own doubts, and thus so much more productive?

There are those who believe that by augmenting brain-derived neurotrophic factor (BDNF), a biochemical naturally produced in the brain and involved in learning and memory, patients might be able to re-learn painful associations so that the memory becomes significantly less intense, and thus less intrusive and ultimately disabling.

In a study published last year in the journal "Science," injecting BDNF into the brains of rats that had been conditioned to associate a sound with a noxious stimulus, scientists found they could mimic the effects of retraining the rats by targeting with BDNF the part of the brain chiefly involved with the extinction of memory, the infralimbic prefrontal cortex. In other words, a memory of safety is created.

Another study, published this month in "The Journal of Neuroscience," examined fibroblast growth factor 2 (FGF2), which had already been shown to enhance the extinction of conditioned fear in rats. The recently published research found that FGF2 infused into the part of the brain known as the amygdala enhanced extinction recall in rats; but extinction training was still needed for this to occur. Interestingly, and potentially much more safe for humans, is the fact that FGF2 was shown to be effective when given systemically also (I am sure there is no argument that a needle into the brain is a little more dangerous than an IV line in the forearm.)

So, while there appears to be overlap between the roles of FGF2 and BDNF in the brain, it appears that these two neurotrophic factors modulate fear extinction via different mechanisms: While BDNF substitutes for extinction training, FGF2 does not, and in fact appears to alter the quality of extinction, rendering rats less susceptible to relapses of fear. And one experiment demonstrated that the use of FGF2 in rats was as effective as four times the amount of extinction training without FGF2. However, it may be too early to make such conclusions, as BDNF and FGF2 may have differential effects on the extinction of fear depending on where in the brain the infusion occurs. Much more investigation is needed.

It certainly would seem that these neurotrophic factors are candidates for future studies in humans. Imagine their utility in the treatment of anxiety and phobias, and in the attenuation of psychologically crippling disorders such as Post Traumatic Stress Disorder.

What is scary in this economy is the potential lack of venture capital which would otherwise possibly move the testing of such interesting agents into the human subject.

 



Why Fear Is Fun