When it comes to the mind and brain, we are so used to hearing that taking a non-materialist approach to life is so much more enriching and fulfilling that taking a materialist approach. Those of us who wish to equate the mind with the output of the brain are often criticised for our reductionist approach. Materialism is ridiculed for its attempts to equate the mind and experience of consciousness as the output of a machine. If brain activity is reducible to patterns of information distributed as binary on/off states in neurons, then you should be able to build conscious robots. As the philosopher John Searle points out, if brains are like computers, and minds are like computer programs then a mind can exist on any suitable computer, whether it's made of gray matter, silicon, or a suitably arranged collection of beer cans. With arguments like that, it is easy to see why materialism is such an easy target for most people.
If the mind is not tethered to the body (and how could a non-physical thing be physical in origin?) then it is spiritual and we are constantly told that those who have a spiritual outlook are much happier. Believers may be happier people but as my colleague Paul Bloom points out, this is more to do with them belonging to the majority group in society rather than a minority of non-believers. For example, atheism is more prevalent in Scandinavian countries but not associated with the same levels of discontent reported in the US. Dualists also tend to endorse free will and reject determinist accounts of behaviour. They are happier in their jobs and outperform colleagues. All in all, materialism gets a pretty bad press.