This is a new recommendation based upon revelations that have been with us most of the decade, regarding the serious cardiovascular and gastrointestinal tract risks associated with NSAID use. Also, it has been long known that the NSAIDs can worsen hypertension and renal function and congestive heart failure, particularly in the older population.
Thus, acetaminophen, commonly known as Tylenol, is the initial systemic therapy of choice for the older patient with chronic pain, assuming of course that the patient does not have serious liver disease. However, the AGS recommendations encourage the consideration of opioid drugs in the elderly individual with persistent pain. And persistent pain is a too-frequent symptom of the older patient, whether it be due to spinal degeneration , arthritis, nocturnal leg pain, or cancer.