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XMRV Controversy Heats Up — Two Important New Studies

As expected, the XMRV virus research has stimulated interest in a host of studies to see if the initial study results can be replicated and to discover treatments for XMRV. Two interesting new studies have been recently reported. Read More

Mutations in the ribonuclease L ( RNASEL) gene & XMRV

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What is needed now is an exhaustive investigation of the ribonuclease L ( RNASEL) gene in individuals diagnosed with XMRV-induced CFS/ME and in individuals diagnosed with HIV-1-induced AIDS in order to establish the exact interrelationship between ribonuclease L ( RNASEL) gene variants and the pathogenesis of retrovirus-induced immunodeficiency syndromes.

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Full gene analysis and specific mutation analysis of the ribonuclease L ( RNASEL) gene in individuals diagnosed with XMRV-induced CFS/ME may reveal the same or perhaps other mutations than hitherto known.

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impairments of the 2-5A synthetase/RNase L pathway

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the 2-5A synthetase/RNase L antiviral pathway

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mutations in the ribonuclease L gene

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RNase L Plays a Role in the Antiviral Response [SV Scherbik - 2006]
ukpmc.ac.uk › Journal List › J Virol › v.80(6); Mar 2006

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the levels of 2-5A synthetase, RNase L

Variation in the ribonuclease L ( RNASEL) gene

www.ihop-net.org/UniPub/iHOP/gs/91766.html

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The 2-5A synthetase/RNase L ... pathways
are part of the antiviral defense

Dr. Robert J.Suhadolnik, PhD

29 Sep 2005

astro.ocis.temple.edu/~rjs/research.html -

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antiviral and antiproliferative activities of
the 2-5A synthetase/RNase L system

N Kon - 1996

www.jbc.org/content/271/33/19983.full

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Changes in
the 2—5A synthetase/RNase L antiviral pathway

CH Schein - 1997

www.nature.com/nbt/journal/v15/n6/abs/nbt0697-529.html

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Functional inactivation of genes
by dominant negative mutations.

doi.wiley.com/10.1111/j.1749-6632.1993.tb35933.x

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the finding that patients
in which RNase L is mutated
exhibit an increased risk ....

Control of virus infection by tumour suppressors

C Munoz-Fontela - 2007

the finding that patients in which RNase L is mutated exhibit an increased risk ...
carcin.oxfordjournals.org/cgi/content/full/28/6/1140

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Upregulation of
the 2-5A synthetase/RNase L antiviral pathway
associated with chronic fatigue syndrome.

pt.wkhealth.com/pt/re/rdd/fulltext.00126839-200203020-00016.htm

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recent detection of two germline mutations
in the RNase L (rnl) gene

P Englebienne - 2003

www.name-us.org/ResearchPages/.../Englebeinne2003RNaseL.pdf

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Germline mutations in the ribonuclease L gene

E Domingo-Gil - 2006

www.springerlink.com/index/0277242206241624.pdf

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Inducible expression of
the 2-5A synthetase/RNase L system

Cancer Gene Therapy

W Hu - 2008

www.nature.com › Journal home › Archive › Original Articles

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These included but were not limited to perturbations

of the 2-5A synthetase/RNase L antiviral pathway

pipeline.corante.com/.../is_xmrv_the_cause_of_chronic_fatigue_syndrome_or_anything.php

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The 2'-5'oligo A (2-5A) synthetase/RNase L

physiolgenomics.physiology.org/cgi/content/full/9/3/145/DC1/3

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Biochemical dysregulation of
the 2-5A synthetase/RNase L antiviral defense

www.bmj.com/cgi/eletters/329/7457/112-b

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Germline mutations in the ribonuclease L gene

26 Ene 2006

ranf.com/pdf/discursos/numero/esteban.pdf

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Impairments of
the 2-5A synthetase/RNase L pathway

www.elsevier.com/homepage/sah/spd/2006sample.../84cagmb.pdf

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molecular genetic analysis of
the ... gene revealed ... mutations

A KOCHAÑSKI - 2004

jag.igr.poznan.pl/2004-Volume-45/1/.../2004_Volume_45_1_95-100.pdf

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Correlation between increased prevalence of AIDS and CFS/ME

The increase in HIV-1 infection since the beginning of the 1980s may constitute an accelerating cofactor in the increase of the prevalence of XMRV since the mid-1980s, because HIV-1 and XMRV have disease-causing co-factors in common such as HHV-6A.

HHV-6A is rare in the general population.

Whereas HHV-6B is common in the general population, HHV-6A may be one of the worst disease-causing cofactors, mainly restricted to diseases such as AIDS, CFS/ME, MS and cancer.

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Literature
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HIV infection is contributing substantially to the increase in other infectious disease epidemics

http://www.determinetest.com/hiv-1%E2%81%842_combo.aspx

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In 1981, the first cases of AIDS (Acquired Immune Deficiency Syndrome)
fohn.net/history-of-aids/

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an outbreak of CFS ... in 1985.
www.ncf-net.org/library/hillary.htm

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the 1985 CFS outbreak in Lyndonville, New York
www.cfs-news.org/namebkgd.htm

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Dr. Cheney & Dr. Peterson documented the historic 1985 CFIDS outbreak in Incline Village ...
fm-cfs.ca/FM-CFS-Quotes.pdf

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SJ Twu - 2004

The HIV/AIDS epidemic in Taiwan started in 1986

link.com/GPI/doi/ref/10.1521/aeap.16.3.5.53.35530

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Late in 1982, the condition began to be referred to as AIDS.
fohn.net/history-of-aids

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Discovery of HIV The near unanimous international consensus is that HIV was first discovered in 1983, ...
wiki.answers.com/Q/Who_discovered_HIV

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BBC - Science & Nature - Horizon - The Hunt for the AIDS vaccine
4 Dec 2003 ... By the time the cause of Aids was discovered in 1984 ...
www.bbc.co.uk

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The first Phase I tests of a candidate vaccine against HIV began in 1987 in the United ...
ww2.aegis.org/news/ips/2001/IP011204.html

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KA Smith - 2003

HIV was discovered in 1983 [8]

www.medimmunol.com/content/2/1/1

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XMRV-induced CFS/ME : An Associative Analysis

XMRV-induced CFS/ME : An Associative Analysis

XMRV (Xenotropic MuLV-related virus)

MuLV is to mice, what FeLV is to cats, and what XMRV is to humans : Gammaretroviruses in Mammalians.

MuLV
MuLV in mice
MuLV
MuLV in murines
MuLV
MuLV and neurodegeneration
MuLV
MuLV and brainstem neurodegeneration
MuLV
MuLV and severe early hemolytic anemia
MuLV
MuLV and later erythroleukemia
MuLV
MuLV and erythroleukemia (red blood cell cancer)
MuLV
MuLV and leukemia (white blood cell cancer)
MuLV
MuLV and cancer
MuLV
MuLV and paralysis
MuLV
MuLV-induced immunodeficiency syndrome

FeLV
FeLV in cats
FeLV
FeLV in felines
FeLV
FeLV and cancer
FeLV
FeLV and lymphomas
FeLV
FeLV and cancer of the lymphocytes (a type of white blood cell)
FeLV
FeLV and pain
FeLV
FeLV and lethargy
FeLV
FeLV and neurodegeneration
FeLV
FeLV and myelopathy
FeLV
FeLV and functional disturbance in the spinal cord
FeLV
FeLV and pathological change in the spinal cord
FeLV
FeLV and degenerative myelopathy
FeLV
FeLV and the spinal cord
FeLV
FeLV and the brainstem
FeLV
FeLV and brainstem lesions
FeLV
FeLV and exercise intolerance
FeLV
FeLV and general malaise
FeLV
FeLV and gastrointestinal disease
FeLV
FeLV and lesions in the gastrointestinal tract
FeLV
FeLV and gastric ulcer
FeLV
FeLV and duodenal ulcer
FeLV
FeLV and bleeding duodenal ulcer
FeLV
FeLV and enteritis
FeLV
FeLV and hematological dysregulation
FeLV
FeLV and viral-infected neutrophils
FeLV
FeLV and neutropenia (low neutrophil count)
FeLV
FeLV and hemolytic anemia
FeLV
FeLV and hemolytic anemia due to viral infections
FeLV
FeLV and normocytic anemia in viral infections
FeLV
FeLV and anemia (low red blood cell count)
FeLV
FeLV and regenerative response to anemia
FeLV
FeLV and regenerative anemia (15% of cases)
FeLV
FeLV and nonregenerative response to anemia
FeLV
FeLV and severe non-regenerative anemia
FeLV
FeLV and dehydration
FeLV
FeLV and hypovolemia (decreased blood volume)
FeLV
FeLV and hypovolemic shock
FeLV
FeLV and reduced blood circulation
FeLV
FeLV and increased blood viscosity
FeLV
FeLV and increased blood viscosity (thickening)
FeLV
FeLV and increased thickening of blood
FeLV
FeLV and elevated blood viscosity
FeLV
FeLV and decreased blood flow rate
FeLV
FeLV and bone marrow suppression
FeLV
FeLV and paralysis
FeLV
FeLV-induced immunodeficiency syndrome
FeLV
FeLV and AZT

XMRV
XMRV in humans
XMRV
XMRV in man
XMRV
XMRV and cancer
XMRV
XMRV and prostate cancer
XMRV
XMRV and pain
XMRV
XMRV and lethargy
XMRV
XMRV and exercise intolerance
XMRV
XMRV and general malaise
XMRV
XMRV and neurodegeneration
XMRV
XMRV and gastrointestinal disease
XMRV
XMRV and CFS/ME
XMRV
XMRV-induced immunodeficiency syndrome (CFS/ME)
XMRV
XMRV and AZT

normocytic anemia and fatigue
normocytic anemia and dizziness
normocytic anemia and weakness
normocytic anemia and fainting
normocytic anemia and headache
normocytic anemia and neck pain
normocytic anemia and nausea
normocytic anemia and recurrent abdominal pain
normocytic anemia and abdominal pain
normocytic anemia and vomiting
normocytic anemia and chronic infection
normocytic anemia and inflammation
normocytic anemia and intense pain episodes
normocytic anemia and cancer

Anemia and decreased blood oxygen capacity
Anemia and reduced oxygen-carrying capacity
Anemia and inadequate tissue oxygen delivery
Anemia and deficiency of oxygen-carrying red blood cells
Anemia and decreased production of blood cells by the bone marrow
Anemia and bone marrow suppression

cancer
cancer and pain
cancer
cancer and fatigue
cancer
cancer and anemia

XMRV-induced CFS/ME is a systemic disease.

XMRV-induced CFS/ME is a debilitating disease, mainly known for its fatigue/pain (red blood cells) & inflammation (white blood cells).

XMRV-induced CFS/ME is a debilitating disease with fatigue/pain (red blood cells) & inflammation (white blood cells).

XMRV-induced CFS/ME is a debilitating disease with fatigue/pain (red blood cell deficiency or anemia, due to bone marrow suppression) & inflammation (white blood cell deficiency or neutropenia due to neutrophil accumulation in tissues, and bone marrow suppression).

XMRV-induced CFS/ME is a debilitating disease, firstly, with outspoken persistent fatigue/pain symptomatology, caused by red blood cell deficiency, mainly normocytic anemia, due to bone marrow suppression, with anemia waxing and waning from regenerative anemia to non-regenerative anemia, and secondly with inflammation, caused by white blood cell deficiency or neutropenia due to neutrophil accumulation in tissues, and bone marrow suppression, mainly causing fulminant neurodegeneration and gastrointestinal disease.

XMRV-induced CFS/ME is a debilitating disease, firstly with outspoken persistent fatigue/pain symptomatology, caused by red blood cell deficiency, mainly normocytic anemia, due to bone marrow suppression, waxing and waning, forthwards and backwards, backwards and forthwards, from non-regenerative anemia to regenerative anemia, and from regenerative anemia to non-regenerative anemia, and secondly with inflammation, caused by white blood cell deficiency or neutropenia due to neutrophil accumulation in tissues, and bone marrow suppression, mainly causing fulminant neurodegeneration and gastrointestinal disease.

XMRV-induced CFS/ME is a debilitating disease, firstly with outspoken persistent fatigue/pain symptomatology, caused by red blood cell deficiency, mainly normocytic anemia, due to bone marrow suppression, with waxing and waning symptomatology indicative of a persistent diseased state hovering between regenerative anemia and non-regenerative anemia, and secondly XMRV-induced CFS/ME is a debilitating disease with inflammation, caused by white blood cell deficiency or neutropenia due to neutrophil accumulation in tissues, and bone marrow suppression, mainly causing fulminant neurodegeneration and gastrointestinal disease.

XMRV-induced CFS/ME is a debilitating disease, firstly with outspoken persistent fatigue/pain symptomatology, caused by red blood cell deficiency, mainly normocytic anemia, due to bone marrow suppression with waxing and waning symptomatology indicative of a persistent diseased state hovering forthwards and backwards, backwards and forthwards, from non-regenerative anemia to regenerative anemia, and from regenerative anemia to non-regenerative anemia, and secondly XMRV-induced CFS/ME is a debilitating disease with recurrent inflammation, caused by white blood cell deficiency or neutropenia due to neutrophil accumulation in tissues, and bone marrow suppression, mainly causing fulminant neurodegeneration and gastrointestinal disease.

Conclusion : Both CFS and MuLV-related diseases are misnomers, because as far as CFS is concerned, fatigue is only a tiny part of the whole, and it has been shown that fatigue in CFS is directly linked to a problem with the red blood cells. So the name CFS is only indirectly referring to the red blood cells, whereas a name for such a debilitating disease should also refer to the white blood cells, because there clearly is a neutrophil problem in CFS/ME. And in FeLV-like and MuLV-like diseases it is the other way round, because the leukemia part in the name of the disease there is only referring to a problem with the white blood cells. So from the perspective of those diseases, it is precisely the other way round, whereas the truth of the matter is that MuLV, FeLV and XMRV are all interrelated, and they are all retrovirus-induced diseases, causing problems not only in the white blood cells (neutrophils), but also in the red blood cells (anemia). So XMRV-induced CFS/ME is a disorder of the white blood cells AND the red blood cells. White blood cells (neutrophils), that's where the inflammation comes in. Red blood cells, that's where the fatigue and pain comes in. White AND red blood cells together stirring up the complete bodily environment, that's where the overwhelming character of the disease comes in, turning XMRV-induced CFS/ME into a systemic disease affecting the body as a whole, just to say the least.

CFS = Chronic Chemotherapy Syndrome

CFS = Chronic Chemotherapy Syndrome

As a matter of fact,

Chronic Fatigue Syndrome

may come down

to be

a Chronic Chemotherapy Syndrome,

because

nature is giving

those persistently infected with XMRV

something like

an improvised kind of chemotherapy against

the oncogenic properties of the retrovirus,

that those people have been infected with.

Nature is also pushing

those infected

to chronically put themselves

literally in the dark

as a kind of dark therapy

which is useful

in order to

increase the levels of melatonin

which have

antioxidant activity

and

anti-cancer properties.

Conclusion :

In CFS/ME,

photophobia should be understood as

nature's last resort

and

alternative method

in the fight against cancer,

for lack of anything better

like for instance M-A1AT.

CFS = Chronic Chemotherapy Syndrome

CFS = Chronic Chemotherapy Syndrome

As a matter of fact, Chronic Fatigue Syndrome may come down to be a Chronic Chemotherapy Syndrome, because nature is giving those persistently infected with XMRV something like an improvised kind of chemotherapy against the oncogenic properties of the retrovirus, that those people have been infected with.

Nature is also pushing those infected to chronically put themselves literally in the dark as a kind of dark therapy which is useful in order to increase the levels of melatonin which may have antioxidant activity and anti-cancer properties.

Conclusion :

In CFS/ME, photophobia should be understood as nature's last resort and alternative method in the fight against cancer, for lack of anything better like for instance M-A1AT.

Retrovirus-induced bone marrow suppression in CFS/ME

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General Conclusion :

XMRV-induced CFS/ME : Retrovirus-induced bone marrow suppression as evidenced by fatigue and encephalitis, caused respectively by anemia and neutropenia.

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Bone marrow suppression and fatigue

Bone marrow suppression and encephalitis

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Bone marrow suppression and anemia

Bone marrow suppression and neutropenia

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Bone marrow suppression and HHV-6A encephalitis

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Bone marrow suppression or myelosuppression
Bone marrow suppression
Bone marrow suppression or myelotoxicity
Bone marrow suppression
Bone marrow suppression or myelotoxic properties
Bone marrow suppression
Bone marrow suppression and decreased number of blood cells produced
Bone marrow suppression
Bone marrow suppression and Retrovirus-Induced Immunodeficiency Disease
Bone marrow suppression
Bone marrow suppression and Retrovirus-induced bone marrow suppression
Bone marrow suppression
Bone marrow suppression and many retroviruses
Bone marrow suppression
Bone marrow suppression and FeLV
Bone marrow suppression
Bone marrow suppression and MuLV
Bone marrow suppression
Bone marrow suppression and MuLV-induced suppression of hematopoietic progenitor cells
Bone marrow suppression
Bone marrow suppression and infection of bone marrow macrophages
Bone marrow suppression
Bone marrow suppression and depressed bone marrow hematopoietic progenitor cell growth
Bone marrow suppression
Bone marrow suppression and bone marrow hematopoietic progenitor cell
Bone marrow suppression
Bone marrow suppression and impaired bone marrow hematopoietic progenitor cell function
Bone marrow suppression
Bone marrow suppression and AIDS
Bone marrow suppression
Bone marrow suppression and chemotherapy
Bone marrow suppression
Bone marrow suppression and HHV-6 encephalitis
Bone marrow suppression
Bone marrow suppression and encephalitis
Bone marrow suppression
Bone marrow suppression and HHV-6A encephalitis
Bone marrow suppression
Bone marrow suppression and Multiple Sclerosis (MS)
Bone marrow suppression
Bone marrow suppression and fatigue
Bone marrow suppression
Bone marrow suppression as evidenced by fatigue
Bone marrow suppression
Bone marrow suppression and neurotoxicity
Bone marrow suppression
Bone marrow suppression and haematologic toxicities
Bone marrow suppression
Bone marrow suppression and hematologic toxicity
Bone marrow suppression
Bone marrow suppression and immunosuppression
Bone marrow suppression
Bone marrow suppression and anemia
Bone marrow suppression
Bone marrow suppression and hemolysis
Bone marrow suppression
Bone marrow suppression and neutropenia
Bone marrow suppression
Bone marrow suppression and AZT
Bone marrow suppression
Bone marrow suppression and chemotherapy-induced myelotoxicity in cancer
Bone marrow suppression
Bone marrow suppression and white blood cell count
Bone marrow suppression

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Pronunciation: Myalgic Encephalomyelitis

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Pronunciation: Myalgic Encephalomyelitis

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Main Entry: my·al·gic

Pronunciation: \mī-ˈal-jik\

http://www.merriam-webster.com/dictionary/myalgic

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Main Entry: en·ceph·a·lo·my·eli·tis

Pronunciation: \in-ˌse-fə-lō-ˌmī-ə-ˈlī-təs\

http://www.merriam-webster.com/dictionary/encephalomyelitis

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Is Chronic PRCA a common finding in XMRV-induced CFS/ME ?

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pure red cell aplasia (PRCA)
pure red cell aplasia
pure red cell aplasia is a type of anemia
pure red cell aplasia
pure red cell aplasia (erythroblastopenia)
pure red cell aplasia
pure red cell aplasia is defined by an isolated severe anemia
pure red cell aplasia
pure red cell aplasia and selective reduction of red blood cell precursors
pure red cell aplasia
pure red cell aplasia is a selective failure of erythropoiesis
pure red cell aplasia
pure red cell aplasia and fatigue
pure red cell aplasia
pure red cell aplasia and lethargy
pure red cell aplasia
pure red cell aplasia and a retrovirus
pure red cell aplasia
pure red cell aplasia and FeLV-C
pure red cell aplasia
pure red cell aplasia and normocytic anemia
pure red cell aplasia
pure red cell aplasia and rare bone marrow disorder
pure red cell aplasia
pure red-cell aplasia is a rare hematologic disorder
pure red cell aplasia
pure red-cell aplasia and characteristic appearance of the bone marrow
pure red-cell aplasia
pure red-cell aplasia and selective marrow erythroid aplasia
pure red-cell aplasia
pure red-cell aplasia and characteristic appearance of the circulating blood
pure red cell aplasia
pure red cell aplasia is a relatively rare condition
pure red cell aplasia
pure red cell aplasia and parvovirus B19 infection
pure red cell aplasia
pure red cell aplasia and hepatitis C infection
pure red cell aplasia
pure red cell aplasia and hemolytic anemia
pure red cell aplasia
pure red cell aplasia and HIV-1 (Parvovirus B19-related anemia)
pure red cell aplasia
pure red cell aplasia and Hematologic Complications of HIV Infection www.bcm.edu/medicine/heme-onc/?PMID=4562
pure red cell aplasia and direct infection of RBC precursors
pure red cell aplasia
pure red cell aplasia and immunocompromised patient
pure red cell aplasia
pure red cell aplasia and parvovirus B19 infection (ulcerative colitis)
pure red cell aplasia
pure red cell aplasia and AZT
pure red cell aplasia
pure red cell aplasia and aplastic crisis
pure red cell aplasia
pure red cell aplasia and B19 virus infection
pure red cell aplasia
pure red cell aplasia and immunocompromised
pure red cell aplasia
pure red cell aplasia and persistent B19 viremia
pure red cell aplasia
pure red cell aplasia and chronic pure red cell aplasia
pure red cell aplasia
pure red cell aplasia and uncompensated anemia with marked weakness and dyspnea (uncomfortable breathing)
pure red cell aplasia
pure red cell aplasia and uncompensated anemia
pure red cell aplasia
pure red cell aplasia and weakness, tachycardia, and dyspnea, so unpleasant that the person avoids exertion
pure red cell aplasia
pure red cell aplasia and viral infection
pure red cell aplasia
pure red cell aplasia and drugs
pure red cell aplasia
pure red cell aplasia and chemicals
pure red cell aplasia
pure red cell aplasia and viral infections
pure red cell aplasia
pure red cell aplasia and hepatitis B
pure red cell aplasia

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Pathogenesis of human parvovirus B19 in rheumatic disease -- Kerr ...
Chronic pure red cell aplasia (PRCA) occurs in immunocompromised subjects ... Chronic fatigue syndrome (CFS) is characterised by debilitating fatigue ...

http://ard.bmj.com/content/59/9/672.short

Ann Rheum Dis 2000;59:672-683
Pathogenesis of human parvovirus B19 in rheumatic disease

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All cats chronically viremic with FeLV-C develop PRCA.
bloodjournal.hematologylibrary.org/cgi/content/full/95/3/1093

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Pure Red Cell Aplasia: eMedicine Hematology
P Schick
3 Nov 2009 ... Pure red cell aplasia (PRCA) describes a condition in which RBC ... Interestingly, pure red cell aplasia can be induced by FeLV-C/Sarma, ..... Pure red-cell aplasia due to parvovirus B19 infection in a patient ...
emedicine.medscape.com/article/205695-overview

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Immune reconstitution syndrome associated with parvovirus B19 ...
P Intalapaporn - 2006
A diagnosis of B19-associated PRCA in HIV-infected patients is further complicated because most patients lack characteristic findings of bone marrow which ...
linkinghub.elsevier.com/retrieve/pii/S0163445305003269

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PRCA). The seroprevalence rates for B19 in unselected persons with HIV infection are high, .... reports of B19-PRCA in HIV-in- ...
www.liebertonline.com/doi/pdf/10.1089/108729100318082

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Parvovirus B19-related anemia in HIV-infected patients.
PR Koduri - 2000
Reports of B19-related anemia in HIV infected patients, however, are infrequent. A partial explanation may be that B19-PRCA is predominantly a complication ...
www.ncbi.nlm.nih.gov/pubmed/12240888

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Chronic pure red cell aplasia caused by parvovirus B19 in AIDS ...
doi.wiley.com/.../(SICI)1096-8652(199905)61:1%3C16::AID-AJH4%3E3.0.CO;...

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Slide 1 - Australian Centre for Blood Diseases
PRCA secondary to parvovirus B19. ■ Parvovirus B19 was first described .... Immunosuppressed ...
www.acbd.monash.org/prca.pdf

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acquired pure red cell aplasia is not uncommon
www.ncbi.nlm.nih.gov/pubmed/1307546

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Dyspnea is another manifestation of anemia because of reduced oxygen carrying capacity of the blood. ...
www.biomedcentral.com/1471-2466/6/23

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Dyspnea is so unpleasant that the person avoids exertion.
www.merck.com/mmhe/sec04/ch039/ch039b.html

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In immunocompromised patients, persistent B19 viremia manifests as chronic pure red cell aplasia. (PRCA). ...
stemcells.alphamedpress.org/cgi/reprint/14/2/151.pdf

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Pure red-cell aplasia (PRCA) is a rare hematologic disorder.
www.springerlink.com/index/55127U8826343536.pdf

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The diagnosis of pure red-cell aplasia was based on the characteristic appearance of the bone marrow and circulating blood.

www.bioportfolio.com/news/btech_021802_1.htm

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chronic pure red cell aplasia (PRCA) has been described in HIV patients. ...
linkinghub.elsevier.com/retrieve/pii/S0163445305003269

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B19 + XMRV = Chronic PRCA with aplastic crisis

B19 + XMRV = Chronic PRCA with aplastic crisis
B19 + XMRV = Chronic PRCA with aplastic crisis
B19 + XMRV = Chronic PRCA with aplastic crisis
B19 + XMRV = Chronic PRCA with aplastic crisis
B19 + XMRV = Chronic PRCA with aplastic crisis
B19 + XMRV = Chronic PRCA with aplastic crisis

aplastic crisis
caused by
human parvovirus B19

Parvovirus B19-related severe anemia
in immunocompromised patients
with retroviral infection,
particularly
HIV-1
FeLV-C
XMRV

chronic
pure red cell aplasia
PRCA
erythroblastopenia
caused by
persistent B19 viremia
is not uncommon
in immunocompromised patients with
a retroviral infection caused by
HIV-1
FeLV-C
XMRV

chronic
pure red cell aplasia
PRCA
erythroblastopenia
caused by
persistent B19 viremia
in patients
chronically viremic with a retrovirus
chronically viremic with HIV-1
chronically viremic with FeLV-C
chronically viremic with XMRV

chronic
pure red cell aplasia
PRCA
erythroblastopenia
caused by
persistent B19 viremia
is
a relatively rare condition
a relatively rare hematologic disorder
in the general population,
where
parvovirus B19
usually only causes mild infection

but

seroprevalence rates for B19 in HIV are high
seroprevalence rates for B19 in FeLV-C are high
seroprevalence rates for B19 in XMRV are high

so

patients
chronically viremic with a retrovirus
chronically viremic with HIV-1
chronically viremic with FeLV-C
chronically viremic with XMRV
chronically develop
an aplastic crisis
caused by human parvovirus B19 (HPV)

An epidemic of aplastic crisis
in patients
chronically viremic with a retrovirus
chronically viremic with HIV-1
chronically viremic with FeLV-C
chronically viremic with XMRV

aplastic crisis
due to
uncompensated anemia
with
marked weakness
marked dyspnea

HPV/B19 + XMRV = Chronic PRCA with aplastic crisis

HPV/B19 + XMRV = Chronic PRCA with aplastic crisis

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Human parvovirus (HPV) B19 causes significant morbidity and mortality ...

www.bloodjournal.org/cgi/content/abstract/bloodjournal;103/2/422

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Human parvovirus (HPV) B19 is a rare cause of encephalitis ...

HPV B19 encephalitis ...

www.neurology.org/cgi/content/full/57/7/1336

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Symptoms caused by acute human parvovirus B19 (HPV-B19) infection can vary considerably, from asymptomatic to severely symptomatic. ...

cat.inist.fr/?aModele=afficheN&cpsidt=20831586

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In both adults and children, HPV B-19 has been known to induce arthritic symptoms ...

HPV B-19 virus infects and lyses erythroid progenitor cells ...

www.stanford.edu/group/virus/parvo/.../parvo.html

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Erythema infectiosum (fifth Disease) is the major clinical manifestation of human parvovirus B19 (HPV B19) infection.

www.nih.go.jp/JJID/58/95.html

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Human parvovirus B19 (HPV B19) infections are usually asymptomatic or benign and ...

Few reports in the literature have implicated HPV B19 as the ...

http://www.informaworld.com/smpp/content~content=a903559419&db=all

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Clinical syndromes commonly associated with HPV B19 are usually not as severe ...

Nevertheless, warnings against transmission of HPV B19 infection ...

ats.ctsnetjournals.org/cgi/content/full/73/4/1098

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HPV B19 is known to be associated with adverse effects on fetuses ...

www.cababstractsplus.org/abstracts/Abstract.aspx?AcNo=20053118505

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Does parvovirus B19 have a role in rheumatoid arthritis?

linkinghub.elsevier.com/retrieve/pii/S0732889307005652

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HPV B19 virus infection with persistent anemia

journals.lww.com › Home › June 27, 2000 - Volume 69 - Issue 12

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The association between aplastic crisis and human parvovirus (HPV) B19 infection

www.koreamed.org/SearchBasic.php?DT=1&RID=484507

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Human parvovirus B19 encephalopathy. ...

HPV-B19 encephalopathy. ...

positive HPV-B19 DNA results. ...

www.fetalneonatal.com/content/70/1/71.2.full.pdf

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Pure Red Cell Aplasia Associated with Parvovirus B19 Infection ...

positive result of HPV B19 DNA has persisted 7 months after the initial ...

informahealthcare.com/doi/pdf/10.1080/10428190127513

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Human parvovirus B19 (HPV B19) infection has been associated with chronic joint complaints in adult patients.

http://www.uptodate.com/patients/content/abstract.do?topicKey=~%2FXXsuaz...

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Human Parvovirus B19 Infection ...

I have had chronic fatigue, knee pain, back/neck pain, & dizziness ever since ....

I would strongly encourage anyone that has been diagnosed with HPV B19, ...

http://autoimmunedisease.suite101.com/article.cfm/human_parvovirus_b19_i...

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Chicago Journals - The Journal of Infectious Diseases ...

the HPV B19 genome ....

chronic fatigue syndrome. Current Pain and Headache Reports 7:5, 333-341 ...

http://www.journals.uchicago.edu/doi/pdf/10.1086/344355?cookieSet=1

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A clinical study of adult human parvovirus B19 infection.

H Hayakawa - 2002

All diagnoses of adult HPV B19 infection were based on positive anti-HPV B19 IgM ...

general fatigue (42.9%), lymph node swelling (38.1%) and edema (38.1%). ...

Chronic Disease; DNA, Viral/analysis; Disease Transmission, Infectious ...

www.ncbi.nlm.nih.gov/pubmed/11993790

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Human parvovirus B19 (HPV-B19) has been identified as the causative agent for fifth disease. Infection with HPV-B19 is common and mostly asymptomatic or presents as mild symptoms such as fever. However, severe complications may occur in certain high-risk groups. HPV-B19 infection occurring during pregnancy may result in fetal anemia and/or fetal death. HPV-B19 infection may cause transient aplastic crisis (TAC) in immunodeficient patients with hemolytic anemia and chronic bone marrow failure. HPV-B19 is transmitted through contact with respiratory tract secretions and vertically from mother to fetus.

http://www.phac-aspc.gc.ca/hcai-iamss/tti-it/ttdi-eng.php

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B19-PRCA-related Brainstem Encephalitis in XMRV-induced CFS/ME

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HPV/B19-PRCA-related Brainstem Encephalitis in XMRV-induced CFS/ME
HPV/B19-PRCA-related Brainstem Encephalitis in XMRV-induced CFS/ME
HPV/B19-PRCA-related Brainstem Encephalitis in XMRV-induced CFS/ME

HPV/B19-PRCA-related Brainstem Encephalitis in XMRV-induced CFS/ME
HPV/B19-PRCA-related Brainstem Encephalitis in XMRV-induced CFS/ME
HPV/B19-PRCA-related Brainstem Encephalitis in XMRV-induced CFS/ME

HPV/B19-PRCA-related Brainstem Encephalitis in XMRV-induced CFS/ME
HPV/B19-PRCA-related Brainstem Encephalitis in XMRV-induced CFS/ME
HPV/B19-PRCA-related Brainstem Encephalitis in XMRV-induced CFS/ME

HPV/B19-PRCA-related Brainstem Inflammation in XMRV-induced CFS/ME
HPV/B19-PRCA-related Brainstem Inflammation in XMRV-induced CFS/ME
HPV/B19-PRCA-related Brainstem Inflammation in XMRV-induced CFS/ME

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HPV/B19 + XMRV = Chronic PRCA with aplastic crisis

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XMRV + HPV/B19 = Chronic PRCA with chronic aplastic crises, manifesting as Brain Stem Encephalitis

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HPV/B19 + XMRV = Chronic PRCA with chronic aplastic crises, manifesting as Brain Stem Encephalitis

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HPV/B19 + XMRV = Chronic PRCA with chronic aplastic crises, manifesting as Chronically Recurrent Brain Stem Encephalitis

------------------------------------------------------------------------------------------------------------------------------------------

HPV/B19 + XMRV = Chronic PRCA with chronic aplastic crises, manifesting as Chronic Brain Stem Encephalitis

------------------------------------------------------------------------------------------------------------------------------------------

HPV/B19 + XMRV = Chronic PRCA with chronic aplastic crises, manifesting as Chronic Brain Stem Encephalitis

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HPV/B19 + XMRV = Chronic PRCA with chronic aplastic crises, manifesting as Chronic Brainstem Encephalitis (CBE)

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(HPV/B19)/XMRV-induced Chronic PRCA with chronic aplastic crises, manifesting as Brain Stem Encephalitis

------------------------------------------------------------------------------------------------------------------------------------------

(HPV/B19)/XMRV-induced Chronic PRCA with chronic aplastic crises, manifesting as Brainstem Encephalitis (CBE)

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(HPV/B19)/XMRV-induced Chronic PRCA with Chronic Aplastic Crises (CAC), manifesting as Brainstem Encephalitis (CBE)

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HPV/B19 - XMRV - Chronic PRCA - Chronic Aplastic Crises (CAC) - Chronically Recurrent Brainstem Encephalitis (CRBE) in CFS/ME

HPV/B19 - XMRV - Chronic PRCA - Chronic Aplastic Crises (CAC) - Chronically Recurrent Brainstem Encephalitis (CRBE) in CFS/ME

HPV/B19 - XMRV - Chronic PRCA - Chronic Aplastic Crises (CAC) - Chronically Recurrent Brainstem Encephalitis (CRBE) in CFS/ME

HPV/B19 - XMRV - Chronic PRCA - Chronic Aplastic Crises (CAC) - Chronically Recurrent Brainstem Encephalitis (CRBE) in CFS/ME

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HPV/B19 - XMRV - C-PRCA - CAC - CRBE in CFS/ME
HPV/B19 - XMRV - C-PRCA - CAC - CRBE in CFS/ME
HPV/B19 - XMRV - C-PRCA - CAC - CRBE in CFS/ME
HPV/B19 - XMRV - C-PRCA - CAC - CRBE in CFS/ME

------------------------------------------------------------------------------------------------------------------------------------------

General Conclusion :

B19-PRCA in XMRV-induced CFS/ME is an underdiagnosed complication associated with advanced immunodeficiency.

B19-related anemia in XMRV-induced CFS/ME causes Chronic PRCA with chronic aplastic crises manifesting as Brain Stem Encephalitis : an underdiagnosed complication associated with advanced immunodeficiency in XMRV-induced CFS/ME.

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Literature

------------------------------------------------------------------------------------------------------------------------------------------

ACQUIRED HAEMOLYITC ANAEMIAS

chronic aplastic crises, leading to reticulocytopenia

bmb.oxfordjournals.org/cgi/reprint/15/1/67.pdf

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Brainstem ... impaired in chronic fatigue syndrome.

http://www.ncbi.nlm.nih.gov/pubmed/8542261

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B19 ... Brain Stem Encephalitis

http://cat.inist.fr/?aModele=afficheN&cpsidt=20441600

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B19-related anemia in ... infected patients ... B19-PRCA is predominantly a complication associated with advanced immunodeficiency. ... underdiagnosed ...

http://www.liebertonline.com/doi/abs/10.1089/108729100318082?cookieSet=1...

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Must-Read Literature :

http://www.liebertonline.com/doi/abs/10.1089/108729100318082?cookieSet=1...

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More literature

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Reports of B19-related anemia in HIV infected patients, however, are infrequent. A partial explanation may be that B19-PRCA is predominantly a complication associated with advanced immunodeficiency. The condition is probably underdiagnosed as well.

http://www.liebertonline.com/doi/abs/10.1089/108729100318082?cookieSet=1...

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Parvovirus B19 infection ... developed brain stem encephalitis ...

http://cat.inist.fr/?aModele=afficheN&cpsidt=20441600

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Infection With Parvovirus B19 Manifesting as Brain Stem Encephalitis

http://cat.inist.fr/?aModele=afficheN&cpsidt=20441600

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A possible parvovirus B19 encephalitis ... lesions involving the brain stem ...

linkinghub.elsevier.com/retrieve/pii/S138665320600415X

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The brain stem is the most primitive part and supports the most basic functions of breathing, blood circulation and digestion. It is also involved in some of the basic aspects of behaviour, mating, aggression and anger. It sits above the spinal cord at the base of the rest of the brain.

http://www.encephalitis.info/Info/TheIllness/TypesEncephalitis/BrainStem...

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Brain Stem Encephalitis. The brain stem is the most primitive part and supports the most basic functions of breathing, blood circulation and digestion.

http://www.encephalitis.info/Info/TheIllness/TypesEncephalitis/BrainStem...

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ACQUIRED HAEMOLYITC ANAEMIAS

Acute transient or chronic aplastic crises, leading to reticulocytopenia, are well-known complications (Crosby &. Rappaport, 1956). ...

bmb.oxfordjournals.org/cgi/reprint/15/1/67.pdf

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Brainstem perfusion is impaired in chronic fatigue syndrome. Costa DC 1995

http://www.ncbi.nlm.nih.gov/pubmed/8542261

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Molecular pathogenesis of feline leukemia virus-induced ...

Feline leukemia virus (FeLV), which is subclassified into three ...

FeLV-C can be uniquely associated with the development of pure red cell aplasia (PRCA). ....

HIV-1 ...

linkinghub.elsevier.com/retrieve/pii/S0165242708000275

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HPV/B19-PRCA-related Brainstem Inflammation in XMRV-induced ME

HPV/B19-PRCA-related Brainstem Inflammation in XMRV-induced CFS/ME
HPV/B19-PRCA-related Brainstem Inflammation in XMRV-induced CFS/ME
HPV/B19-PRCA-related Brainstem Inflammation in XMRV-induced CFS/ME

General Conclusion :

B19-PRCA in XMRV-induced CFS/ME is an underdiagnosed complication associated with advanced immunodeficiency.

B19-related anemia in XMRV-induced CFS/ME causes Chronic PRCA with chronic aplastic crises manifesting as Brain Stem Encephalitis : an underdiagnosed complication associated with advanced immunodeficiency in XMRV-induced CFS/ME.

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Literature

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Several case reports have associated CFS with parvovirus B19 (Jacobson et al. 1997; Kerr et al. 2002), and treatment with immunoglobulin has been successful in some cases (Kerr et al. 2003).

http://diss.kib.ki.se/2006/91-7140-828-2/thesis.pdf

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B19-related CFS has been associated with elevated levels of IFNy and TNFa (Kerr et al. 2003)

http://diss.kib.ki.se/2006/91-7140-828-2/thesis.pdf

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Infection With Parvovirus B19 Manifesting as Brain Stem Encephalitis

http://cat.inist.fr/?aModele=afficheN&cpsidt=20441600

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Brainstem perfusion is impaired in chronic fatigue syndrome. [Costa DC - 1995]
http://www.ncbi.nlm.nih.gov/pubmed/8542261

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Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome

Originally published in Science Express on 8 October 2009
Science 23 October 2009:
Vol. 326. no. 5952, pp. 585 - 589

Vincent C. Lombardi
Francis W. Ruscetti
Jaydip Das Gupta
Max A. Pfost
Kathryn S. Hagen
Daniel L. Peterson
Sandra K. Ruscetti
Rachel K. Bagni
Cari Petrow-Sadowski
Bert Gold
Michael Dean
Robert H. Silverman
Judy A. Mikovits

http://www.sciencemag.org/cgi/content/abstract/1179052

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Antibody to parvovirus B19 nonstructural protein is associated with chronic arthralgia in patients with Chronic Fatigue Syndrome / Myalgic Encephalomyelitis (CFS/ME)

Published online ahead of print on 9 December 2009
J Gen Virol (2009)

Society for General Microbiology

Jonathan R. Kerr
John Gough
Selwyn C. M. Richards
Janice Main
Derek Enlander
Michelle McCreary
Anthony L. Komaroff
John K. Chia

St George's University of London;
Poole Hospital NHS Trust;
Imperial College London;
New York ME/CFS Service;
Brigham & Women's Hospital, Harvard Medical School;
ID Med, Torrance, CA

http://vir.sgmjournals.org/cgi/content/abstract/vir.0.017590-0v1

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Severe Chronic Aplastic Crises (Prolonged Reticulocytopenia)

In XMRV-induced CFS/ME
In XMRV-induced CFS/ME
In XMRV-induced CFS/ME

chronic aplastic crises
chronic aplastic crises
chronic aplastic crises

more prolonged crises with severe reticulocytopenia
more prolonged crises with severe reticulocytopenia
more prolonged crises with severe reticulocytopenia

Prolonged reticulocytopenia in autoimmune hemolytic anemia
Prolonged reticulocytopenia in autoimmune hemolytic anemia
Prolonged reticulocytopenia in autoimmune hemolytic anemia

Reticulocytopenic immune hemolytic anemia
Reticulocytopenic immune hemolytic anemia
Reticulocytopenic immune hemolytic anemia

Reticulocytopenia
Reticulocytopenia
Reticulocytopenia
and "absence" of red cell autoantibodies
and "absence" of red cell autoantibodies
and "absence" of red cell autoantibodies
in immune haemolytic anaemia.
in immune haemolytic anaemia.
in immune haemolytic anaemia.

severe chronic aplastic crisis (also known as reticulocytopenia)
severe chronic aplastic crisis (also known as reticulocytopenia)
severe chronic aplastic crisis (also known as reticulocytopenia)

Inadequately low erythropoietin levels
Inadequately low erythropoietin levels
Inadequately low erythropoietin levels

Inadequate low EPO levels in anemic patients
Inadequate low EPO levels in anemic patients
Inadequate low EPO levels in anemic patients

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Literature

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Reticulocytopenia, or "aplastic crisis", is the medical term for an abnormal decrease of reticulocytes in the body.

en.wikipedia.org/wiki/Reticulocytopenia

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Reticulocytopenia in severe autoimmune hemolytic anemia (AIHA) of ...

G Hauke - 1983

acute aplastic crisis or more prolonged crises with severe reticulocytopenia were observed as important but rare complications. ...

www.springerlink.com/index/N46784023761R3H0.pdf

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Reticulocytopenia and "absence" of red cell autoantibodies in ...

UM Hegde - 1977

Demonstration of two distinct antibodies in autoimmune hemolytic anemia with reticulocytopenia and red cell aplasia.

Exp Hematol. 1984 Nov; 12(10):788-93. ...

www.ncbi.nlm.nih.gov/pmc/articles/PMC1632621/

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J Greenberg - 1980

Prolonged reticulocytopenia in autoimmune hemolytic anemia of childhood

linkinghub.elsevier.com/retrieve/pii/S0022347680802691

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Reticulocytopenia and "absence" of red cell autoantibodies in immune haemolytic anaemia.

[U M Hegde - 1977]

A raised reticulocyte count is common in patients with immune or autoimmune haemolytic anaemia, and the result of the direct antiglobulin test (DAGT) is usually positive because of IgG or IgG and complement components on the red cells. We report on three patients who had low reticulocyte counts when they were most anaemic, and in whom no red cell autoantibodies could be detected by the DAGT.

We postulate that reticulocytes may be selectively destroyed if antibodies are directed against antigenic sites on these young red cells, thus giving rise to a population of cells whose antigenic sites are poorly expressed. This theory might explain the low reticulocyte counts and the "absence" of antibodies (as tested by the DAGT) in such patients.

Radioisotopic studies with 51Cr and 59Fe may provide useful information on the rate and sites of red cell destruction.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1632621/

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Aplastic crisis, characterized by development of severe anemia and reticulocytopenia, was initially described in patients with ...

pdfs.journals.lww.com/.../Aplastic_Crisis_in_Sickle_Cell_Disorders__Bone.9.pdf

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Reticulocytopenic immune hemolytic anemia in an AIDS patient.

A Pan - 1992

CONCLUSIONS: IHA is rare in HIV infected patients and frequently is characterized by reticulocytopenia.

gateway.nlm.nih.gov/MeetingAbstracts/102201203.html

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In anemic HIV patients reticulocytopenia is a consistent finding.
In anemic HIV patients reticulocytopenia is a consistent finding.
In anemic HIV patients reticulocytopenia is a consistent finding.

---

Pathogenesis and pathophysiology of anemia in HIV infection

KA KREUZER - 1997

In anemic HIV patients reticulocytopenia is a consistent finding. Additionally, inadequately low endogenous erythropoietin concentrations have been ...

cat.inist.fr/?aModele=afficheN&cpsidt=2068334

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TA GODWIN - 2000

Reticulocytopenia is common in HIV-associated anemia. Endogenous erythropoietin has been reported to be inadequately low, and ...

www.liebertonline.com/doi/pdf/10.1089/10872910050206595

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ACQUIRED HAEMOLYITC ANAEMIAS

AH ANAEMIAS

Acute transient or chronic aplastic crises, leading to reticulocytopenia, are well-known complications (Crosby &. Rappaport, 1956).

bmb.oxfordjournals.org/cgi/reprint/15/1/67.pdf

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or HIV, in which is cause of a severe chronic aplastic crisis (also known as reticulocytopenia). Parvovirus B19 is also directly involved, with a mother-to- ...

www.nanogenad.net/pdf/ParvoB19_EN.pdf

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Inadequate erythropoietin response to anaemia in HIV patients ...
Inadequately low erythropoietin levels and peripheral ....

doi.wiley.com/10.1046/j.1365-2141.1997.d01-2031.x

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P Van Der Meer - 2007

Resistance to Endogenous Erythropoietin Predicts Survival in ...

Inadequate low EPO levels were observed in 30 anemic patients (39%) and ...

circ.ahajournals.org/cgi/content/meeting_abstract/116/16.../II_757-b

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Prevalences of FeLV and XMRV infection : both 3.7%

Prevalences of FeLV and XMRV infection : both 3.7%

• FeLV 3.7% in USA - Gainesville, FL (2002)
• XMRV 3.7% in USA (2009)

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Prevalence of FeLV in stray cat population in U.S.

• 1-2% Boston, MA (1975)
• 3.7% in Gainesville, FL (2002)
• 5.3% Raleigh, NC (2002)

Prevalence in indoor cat population less than 1%

http://www.docstoc.com/docs/433441/Feline-Leukemia-Virus-FeLV-Feline-Imm...

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In contrast, XMRV gag sequences were detected in 8 of 218 (3.7%) PBMC DNA specimens from healthy individuals.

www.sciencemag.org/cgi/.../full/sci;...XMRV...

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Prevalence of feline leukemia virus infection ...

IT Lee - 2002

In Gainesville, overall prevalence of FeLV infection was 3.7% ...

avmajournals.avma.org/doi/pdf/10.2460/javma.2002.220.620

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Coombs-Negative Hemolytic Anemia in advanced CFS/ME

------------------------------------------------------------------------------------------------------------------------------------------

Immune-mediated hemolytic anemia
Immune-mediated hemolytic anemia
Immune-mediated hemolytic anemia

------------------------------------------------------------------------------------------------------------------------------------------

Both
regenerative
regenerative
regenerative
and
non-regenerative
non-regenerative
non-regenerative
immune mediated hemolytic anemias

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regenerative
regenerative
regenerative

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a clinical picture consisting of an acute onset anemia
a clinical picture consisting of an acute onset anemia
a clinical picture consisting of an acute onset anemia

The anemia is regenerative
The anemia is regenerative
The anemia is regenerative
if the reticulocyte percentage is over 2.5% to 3%
if the reticulocyte percentage is over 2.5% to 3%
if the reticulocyte percentage is over 2.5% to 3%

an acute onset anemia that is often strongly regenerative
an acute onset anemia that is often strongly regenerative
an acute onset anemia that is often strongly regenerative

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often strongly regenerative,
often strongly regenerative,
often strongly regenerative,
are direct Coombs positive
are direct Coombs positive
are direct Coombs positive

often strongly regenerative, are direct Coombs positive
often strongly regenerative, are direct Coombs positive
often strongly regenerative, are direct Coombs positive

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nonregenerative
nonregenerative
nonregenerative

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associated with advanced immunodeficiency
associated with advanced immunodeficiency
associated with advanced immunodeficiency

pure red cell aplasia
pure red cell aplasia
pure red cell aplasia
and nonregenerative immune-mediated anemia
and nonregenerative immune-mediated anemia
and nonregenerative immune-mediated anemia

chronic history of lethargy and weakness,
chronic history of lethargy and weakness,
chronic history of lethargy and weakness,
be Coombs negative
be Coombs negative
be Coombs negative

non-regenerative anemia,
non-regenerative anemia,
non-regenerative anemia,
with a chronic history of lethargy and weakness,
with a chronic history of lethargy and weakness,
with a chronic history of lethargy and weakness,
be Coombs negative
be Coombs negative
be Coombs negative

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Literature

------------------------------------------------------------------------------------------------------------------------------------------

pure red cell aplasia and nonregenerative immune-mediated anemia

Immune-mediated hemolytic anemia in cats referring to Veterinary ...

E Fathi

Idiopathic pure red cell aplasia and nonregenerative immune-mediated anemia ...

www.shirazu.ac.ir/en/files/extract_file.php?file_id=1132

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Central Immune Mediated Hemolytic Anemia in a 10 year old female ...

S Marks - 2009

25 Mar 2009 ... often strongly regenerative, are direct Coombs positive, .... viral causes (FeLV, ... Both regenerative and non-regenerative immune mediated hemolytic anemias ... Mediated Haemolytic Anaemia and Pure Red Cell Aplasia ...

dspace.library.cornell.edu:8080/.../1/Marks-Stephanie-seminar2009.pdf

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Veterinary Hematology and Clinical Chemistry ...

2004 - Medical - 618 pages

Finally, certain strains of FeLV virus (subgroup C) cause pure red cell aplasia.

RED C HYPOPLASIA Nonregenerative anemia may result from abnormalities that ...

books.google.com/books?isbn=0781768500...

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ANEMIA IN THE CAT

The anemia is regenerative if the reticulocyte percentage is over 2.5% to 3%; ... Direct Coombs' test usually positive (if immune-mediated) ... Red Blood Cell Aplasia/Hypoplasia. FeLV- or FIV-related in most cases ...

www.walthamusa.com/articles/COUTO97.pdf

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Hematology

Susan M. Cotter - 2001 - Medical - 147 pages
Nonregenerative anemia may be macrocytic in some cats with anemia secondary to feline leukemia virus (FeLV) or myelodysplasia (see Chapters 24 and 26), ...

books.google.com/books?isbn=1893441369...

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nonregenerative anemia - Disease & Conditions

For instance, a cat with FeLV infection can have nonregenerative anemia alone, ... A positive Coomb's test with species-specific reagents provides support for ... Erythroid hypoplasia or aplasia confirms nonregenerative anemia. ...

https://www.vetconnect.com.au/5min/data/01960197.htm

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Primary Immune-Mediated Hemolytic Anemia in 19 Cats: Diagnosis ...
Two of these cats had hemolytic anemia and were FeLV positive (secondary IMHA). Another cat ..... mediated anemia. In cats with a negative Coombs' test ...

doi.wiley.com/10.1111/j.1939-1676.2006.tb02836.x

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Central Immune Mediated Hemolytic Anemia in a 10 year old female ...

S Marks - 2009

25 Mar 2009 ... Immune mediated hemolytic anemia (IMHA) is a common disease in dogs and cats. ... chronic history of lethargy and weakness, be Coombs negative, and lack a spherocytosis ... viral causes (FeLV, ...

dspace.library.cornell.edu:8080/.../1/Marks-Stephanie-seminar2009.pdf

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Hemolytic anemia in cats: Infectious or immune-mediated ...
Hemolytic anemia is usually secondary to a primary infectious cause ... FeLV/FIV, primary bone marrow disorders and anemia of chronic disease. ... A Coombs' test may be performed, but a negative test does not rule out hemolytic anemia. ...

veterinarycalendar.dvm360.com/avhc/article/articleDetail.jsp?id...

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Central immune mediated hemolytic anemia in a 10 year old female Dachshund

25-Mar-2009

Immune mediated hemolytic anemia (IMHA) is a common disease in dogs and cats. Patients with IMHA present with a clinical picture consisting of an acute onset anemia that is often strongly regenerative, are direct Coombs positive, have a spherocytosis, and a leukocytosis with a left shift. However, some patients can present with a non-regenerative anemia, with a chronic history of lethargy and weakness, be Coombs negative, and lack a spherocytosis or leukocytosis with a left shift. This paper focuses on the history, diagnosis, treatment, prognosis, and outcome of a 10 year old female Dachshund with a non-regenerative IMHA.

http://dspace.library.cornell.edu:8080/handle/1813/12755

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Intravenous immunoglobulins in autoimmune- or parvovirus B19 ...

L Mouthon - 2005

Pure red-cell aplasia (PRCA) is defined as the absence of mature erythroid .... associated with advanced immunodeficiency in HIV-infected patients [27]. ...

linkinghub.elsevier.com/retrieve/pii/S1568997204002150

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XMRV-ME + CMV = Coombs-negative severe haemolytic anaemia

XMRV-induced CFS/ME
XMRV-induced CFS/ME
XMRV-induced CFS/ME

Human Herpesvirus HHV-5
Human Herpesvirus HHV-5
Human Herpesvirus HHV-5

Cytomegalovirus (CMV/HHV-5)
Cytomegalovirus (CMV/HHV-5)
Cytomegalovirus (CMV/HHV-5)

cytomegalovirus infection
cytomegalovirus infection
cytomegalovirus infection

Coombs-negative severe haemolytic anaemia
Coombs-negative severe haemolytic anaemia
Coombs-negative severe haemolytic anaemia

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Literature

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Coombs-negative severe haemolytic anaemia in an immunocompetent adult following cytomegalovirus infection

European Journal of Clinical Microbiology & Infectious Diseases
Volume 23, Number 11 / November, 2004
Pages 844-847

http://www.springerlink.com/content/44yqrgpy3ckd1anq/

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Herpesviruses: HHV-5

Human Cytomegalovirus (HCMV/HHV-5).

cmbi.bjmu.edu.cn/www-learn/micro-ac-uk/335/HHV5.html

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Symptoms

Most people infected with CMV who are otherwise healthy experience few if any symptoms. In fact, many people never know they have the virus. The type and seriousness of a CMV infection usually depend on your overall health.

When first infected (primary CMV), some adults may have symptoms similar to mononucleosis. Signs and symptoms of primary CMV include:

* Fatigue
* Weakness
* Night sweats
* Prolonged fever
* Swollen glands or sore throat or both
* Loss of appetite or weight loss or both
* Muscle aches or joint pain or stiffness
* General feeling of illness, discomfort or uneasiness

When the cause of these symptoms is CMV, you still may not know you have the virus, because the symptoms are usually mild and short-lived and are also common in other illnesses.

Signs and symptoms in adults with compromised immunity
If you're an adult with a weakened immune system (immunocompromised), CMV can attack specific organs. This can result in signs and symptoms in the:

* Eyes, including visual impairment and blindness
* Lungs, including pneumonia with low blood oxygen (hypoxemia)
* Gastrointestinal system, including diarrhea and ulcerations with bleeding
* Liver, including hepatitis, most often characterized by a prolonged, unexplained fever
* Brain, including inflammation of the brain (encephalitis), with behavioral changes, seizures and coma

http://www.mayoclinic.com/health/cmv/ds00938/dsection=symptoms

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Coinfection with (CMV, HHV-5) and EBV in XMRV-induced CFS/ME.

------------------------------------------------------------------------------------------------------------------------------------------

General Conclusion

------------------------------------------------------------------------------------------------------------------------------------------

Infection with human cytomegalovirus (CMV, HHV-5) may be a major cause of disease and death in XMRV-induced CFS/ME.

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Coinfection with CMV and EBV may be a major cause of disease and death in XMRV-induced CFS/ME.

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Coinfection with CMV and EBV may be a major cause of disease and death in XMRV-induced CFS/ME, with severe symptomatology and features of gastrointestinal disorders due to neurological disease.

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Human cytomegalovirus-induced lung infection may be a frequent cause of major concern to those involved with XMRV-induced CFS/ME.

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Literature

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* Lungs, including pneumonia with low blood oxygen (hypoxemia)

* Gastrointestinal system, including diarrhea and ulcerations with bleeding

* Brain, including inflammation of the brain (encephalitis), with behavioral changes, seizures and coma

http://www.mayoclinic.com/health/cmv/ds00938/dsection=symptoms

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Detection of human cytomegalovirus (CMV, HHV-5) DNA in clinical specimens is considered a cornerstone in the diagnosis of HHV-5 disease. ...

www.springerlink.com/index/M94X56R56200K070.pdf

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Coinfection with CMV and EBV in Indian patients with HIV/AIDS.

gateway.nlm.nih.gov/MeetingAbstracts/102229594.html

------------------------------------------------------------------------------------------------------------------------------------------

Cytomegalovirus and Epstein-Barr virus coinfection in ...
First, coinfection with CMV and EBV is likely to elicit a strong T cell response.
doi.wiley.com/10.1002/jmv.21527

------------------------------------------------------------------------------------------------------------------------------------------

Cytomegalovirus infection in lung transplant recipients ...

The impact of ganciclovir-resistant cytomegalovirus infection after lung ...

www.utdol.com/patients/content/topic.do?topicKey...

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human cytomegalovirus-induced lung infection

www.springerlink.com/index/H077177567U05889.pdf

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Correlation of interstitial pneumonia with human cytomegalovirus ...

www.springerlink.com/index/H077177567U05889.pdf

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Cytomegalovirus infection is a common herpesvirus infection with a wide range of ...

These drugs have serious side effects and may not cure the infection. ...

www.merck.com/mmhe/sec17/ch198/ch198h.html

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Human cytomegalovirus (HCMV) resistance to antiviral drugs

jac.oxfordjournals.org/cgi/reprint/53/3/536.pdf

------------------------------------------------------------------------------------------------------------------------------------------

Management of Cytomegalovirus Infections

Treatment of CMV Infection

CMV lung infection in AIDS patients

virology-online.com/viruses/CMV5.htm

------------------------------------------------------------------------------------------------------------------------------------------

Infection with CMV is a major cause of disease and death in immunocompromised patients

http://www.news-medical.net/?tag=/Cytomegalovirus

------------------------------------------------------------------------------------------------------------------------------------------

Cytomegalovirus (CMV) is a member of the herpes virus group, which includes herpes simplex virus types 1 and 2, varicella-zoster virus (which causes chickenpox), and Epstein-Barr virus (which causes infectious mononucleosis). Infection with CMV is a major cause of disease and death in immunocompromised patients, including organ transplant recipients, patients undergoing hemodialysis, patients with cancer, patients receiving immunosuppressive drugs, and HIV-infected patients. While drugs are available for treatment of these conditions, the primary drug choices carry significant side effects and warnings. Currently, there are no anti-CMV drugs indicated for treatment of primary CMV infection during pregnancy resulting in infections that can have catastrophic consequences to the newborn.

http://www.news-medical.net/?tag=/Cytomegalovirus

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cytomegalovirus infection
cytomegalovirus infection
cytomegalovirus infection
exacerbates inflammatory bowel disease
exacerbates inflammatory bowel disease
exacerbates inflammatory bowel disease

Research suggests latent cytomegalovirus infection exacerbates inflammatory bowel disease ...

www.news-medical.net/?tag=/Cytomegalovirus

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cytomegalovirus (CMV) ...

overexpression after lung infection. ...

www.jci.org/articles/view/3214/version/1/files/pdf

------------------------------------------------------------------------------------------------------------------------------------------

... induce bacteremia after lung infection and results in a nonprogressive course unless ...

Murine cytomegalovirus pneumonia.

ajplung.physiology.org/cgi/content/full/294/3/L387

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POTENTIAL ROLES OF HUMAN CYTOMEGALOVIRUS UL97 AND UL27 IN ... after lung infection ...

www2.utmb.edu/nsrf/2008Program.pdf

------------------------------------------------------------------------------------------------------------------------------------------

Inhibition of murine cytomegalovirus lung infection and interstitial pneumonitis

www.ncbi.nlm.nih.gov/pmc/articles/PMC180213/

------------------------------------------------------------------------------------------------------------------------------------------

methods for the diagnosis of cytomegalovirus lung infection

linkinghub.elsevier.com/retrieve/pii/0166093488901474

------------------------------------------------------------------------------------------------------------------------------------------

Rapid diagnosis of cytomegalovirus lung infection

https://www.researchgate.net/.../15329297_Rapid_diagnosis_of_cytomegalov......

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Correlation of interstitial pneumonia with human cytomegalovirus ...

CA Müller - 1995

human cytomegalovirus-induced lung infection and graft-versus-host disease after bone marrow transplantation.

www.springerlink.com/index/H077177567U05889.pdf

-----------------------------------------------------------------------------------------------------------------------------------------

Host genetic factors influence murine cytomegalovirus lung infection and interstitial pneumonitis.

www.cababstractsplus.org/Abstracts/Abstract.aspx?AcNo=19850188483

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T Beutler - 2003

Pathogenesis of cytomegalovirus lung infection is not fully understood. Aside from a direct virus-induced pathogenesis leading to irreversible damage to ...

www.ajrcmb.org/cgi/content/full/28/1/86

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Host genetic factors influence murine cytomegalovirus lung infection and interstitial pneumonitis. J. Gen. Virol. 65: 2121–2128. ...

www.nature.com › Journal home › Archive › Original Articles

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The relation of viral replication to interstitial pneumonitis in murine cytomegalovirus lung infection. J Infec Dis 1985; 151:454- 458. 72. ...

books.google.com/books?isbn=082478572X...

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People with suppressed immune systems are at increased risk for contracting a lung infection known as Cytomegalovirus ...

www.ayushveda.com/.../symptoms-and-treatment-of-cytomegalovirus-cmv-pneu...

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Cytomegalovirus Pneumonia in AIDS

Rapid detection of cytomegalovirus pulmonary infection
chestjournal.chestpubs.org/content/113/4/919.full.pdf

------------------------------------------------------------------------------------------------------------------------------------------

Lungs are a major organ of cytomegalovirus latency and recurrence.

www.liebertonline.com/doi/abs/10.1089/08828240050144626

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cytomegalovirus (CMV) reactivation

www.mdconsult.com/das/journal/view/0/N/22799879?ja...PAGE...

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CMV + XMRV-induced CFS/ME => PTSD

------------------------------------------------------------------------------------------------------------------------------------------

General Conclusion

------------------------------------------------------------------------------------------------------------------------------------------

CMV + XMRV-induced CFS/ME => PTSD
CMV + XMRV-induced CFS/ME => PTSD
CMV + XMRV-induced CFS/ME => PTSD

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CMV may cause PTSD in XMRV-induced CFS/ME
CMV may cause PTSD in XMRV-induced CFS/ME
CMV may cause PTSD in XMRV-induced CFS/ME

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Cytomegalovirus (HHV-5, CMV) infections
Cytomegalovirus (HHV-5, CMV) infections
Cytomegalovirus (HHV-5, CMV) infections

------------------------------------------------------------------------------------------------------------------------------------------

Xenotropic murine leukemia virus-related virus (XMRV) is a new human gammaretrovirus
Xenotropic murine leukemia virus-related virus (XMRV) is a new human gammaretrovirus
Xenotropic murine leukemia virus-related virus (XMRV) is a new human gammaretrovirus

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chronic fatigue syndrome/myalgic encephalomyelitis
chronic fatigue syndrome/myalgic encephalomyelitis
chronic fatigue syndrome/myalgic encephalomyelitis

------------------------------------------------------------------------------------------------------------------------------------------

Posttraumatic Stress Disorder (PTSD)
Posttraumatic Stress Disorder (PTSD)
Posttraumatic Stress Disorder (PTSD)

------------------------------------------------------------------------------------------------------------------------------------------

Cytomegalovirus (CMV) infection
Cytomegalovirus (CMV) infection
Cytomegalovirus (CMV) infection

a serious cause of morbidity and mortality
a serious cause of morbidity and mortality
a serious cause of morbidity and mortality

can be life-threatening
can be life-threatening
can be life-threatening

can cause life-threatening events
can cause life-threatening events
can cause life-threatening events

can be a life-threatening event
can be a life-threatening event
can be a life-threatening event

can be life-threatening events
can be life-threatening events
can be life-threatening events

in an immunocompromised host
in an immunocompromised host
in an immunocompromised host

events that may constitute trauma
events that may constitute trauma
events that may constitute trauma

trauma, defined as an event that is life-threatening
trauma, defined as an event that is life-threatening
trauma, defined as an event that is life-threatening

The nature and severity of the event
The nature and severity of the event
The nature and severity of the event

giving rise to PTSD
giving rise to PTSD
giving rise to PTSD

Posttraumatic Stress Disorder (PTSD)
Posttraumatic Stress Disorder (PTSD)
Posttraumatic Stress Disorder (PTSD)

------------------------------------------------------------------------------------------------------------------------------------------

Literature

------------------------------------------------------------------------------------------------------------------------------------------

Detection of an Infectious Retrovirus, XMRV, in Blood Cells of ...

VC Lombardi - 2009

Xenotropic Murine Leukemia Virus-Related Virus

www.sciencemag.org › Science Magazine › 23 October 2009

------------------------------------------------------------------------------------------------------------------------------------------

S Kim - 2008

Xenotropic murine leukemia virus-related virus (XMRV) is a new human gammaretrovirus

jvi.asm.org/cgi/content/short/82/20/9964

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chronic fatigue syndrome/myalgic encephalomyelitis
chronic fatigue syndrome/myalgic encephalomyelitis
chronic fatigue syndrome/myalgic encephalomyelitis

jcp.bmjjournals.com › Table of Contents

------------------------------------------------------------------------------------------------------------------------------------------

symptoms of PTSD ... in a sample of HIV-infected ...

www.springerlink.com/index/T154N7XT430P61V7.pdf

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HIV-related PTSD

www.springerlink.com/index/y5556882w5472722.pdf

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PTSD and HIV often comorbid.

www.encyclopedia.com/doc/1G1-176473834.html

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HIV-1 Associated Opportunistic Infections - Cytomegalovirus ...

In the setting of HIV infection, cytomegalovirus (CMV) can affect both the central and peripheral nervous systems.

emedicine.medscape.com › ... › Neurological Infections

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Cytomegalovirus (CMV) infection in renal transplanted patients is a serious cause of morbidity and mortality

linkinghub.elsevier.com/retrieve/pii/S0041134506005586

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CMV infection in an immunocompromised host can be life-threatening.

The severity of the disease depends on the strength of the person's ...

www.nlm.nih.gov/medlineplus/ency/article/000663.htm

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Causes of Posttraumatic Stress Disorder (PTSD).

Virtually any trauma, defined as an event that is life-threatening .

www.medicinenet.com/posttraumatic_stress.../article.htm

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can be life-threatening events

journals.cambridge.org/production/action/cjoGetFulltext?fulltextid...

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can be a life-threatening event

ons.metapress.com/index/8003536N87H1T836.pdf

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Cytomegalovirus-induced PTSD in CFS/ME

------------------------------------------------------------------------------------------------------------------------------------------

General Conclusion

------------------------------------------------------------------------------------------------------------------------------------------

Cytomegalovirus-induced PTSD in CFS/ME

Cytomegalovirus (CMV) infection - a serious cause of morbidity and mortality - can be life-threatening, and can cause life-threatening events in an immunocompromised host (e.g. someone with XMRV-induced CFS/ME). These life-threatening events may constitute trauma. Trauma defined as an event that is life-threatening, or a series of events that are life-threatening. The nature and severity of the events giving rise to Post-Traumatic Stress Disorder (PTSD).

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Human Cytomegalovirus, also called human herpesvirus 5 (HCMV/CMV/HHV-5)

------------------------------------------------------------------------------------------------------------------------------------------

Comparative epidemiology of HIV and XMRV retroviruses

------------------------------------------------------------------------------------------------------------------------------------------

General Conclusion

------------------------------------------------------------------------------------------------------------------------------------------

Comparative epidemiology of HIV and XMRV retroviruses :

[1]

HIV linked to AIDS : HIV/AIDS

AIDS is the later stage of HIV infection

More than 1 million people in the USA have AIDS

A History of Chronic Denial

[2]

XMRV linked to CFS/ME : XMRV/{CFS/ME}

CFS/ME is the later stage of XMRV infection

More than 1 million people in the USA have CFS/ME

A case of Chronic Denial

------------------------------------------------------------------------------------------------------------------------------------------

Literature

------------------------------------------------------------------------------------------------------------------------------------------

The CDC states at the end of 2003 about 1 to 1.2 million people in the US were living with HIV/AIDS.

www.webmd.com/hiv-aids/default.htm

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More than 1 million people in the United States have chronic fatigue syndrome (CFS), ...

www.cdc.gov/cfs/pdf/UnderstandingCFS.pdf

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[Comparative epidemiology of HTLV and HIV retroviruses]

by P Tuppin - 1993

... or neurological (TSP/HAM) disorders than HIV linked to AIDS. Finally, prevention by vaccine should be achievable much earlier for HTLVs than for HIVs.

...

www.ncbi.nlm.nih.gov/pubmed/7908602

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AIDS and HIV Health Center - WebMD

The CDC states at the end of 2003 about 1 to 1.2 million people in the US were living with HIV/AIDS.

www.webmd.com/hiv-aids/default.htm

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More than 1 million people in the United States have chronic fatigue syndrome (CFS), ...

www.cdc.gov/cfs/pdf/UnderstandingCFS.pdf

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Originally published in Science Express on 8 October 2009

Science 23 October 2009:

Vol. 326. no. 5952, pp. 585 - 589

Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome

Vincent C. Lombardi

http://www.sciencemag.org/cgi/content/abstract/1179052

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F Brauer - 2009

It took two years for scientists to identify a virus, which became known as HIV, linked to AIDS. In 1987, a new drug (AZT) was developed which delayed ...

www.biomedcentral.com/1471-2458/9/S1/S2

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EH Chi - 1996

'82 to 85: HIV linked to AIDS.

'86: HIV gained international attention,

'89: large grants supporting HIV

portal.acm.org/ft_gateway.cfm?id=245041&type=pdf

------------------------------------------------------------------------------------------------------------------------------------------

immunization - Ministry of Health Search

The HIV linked to AIDS may allow cancers to grow by suppressing the immune system.

search.moh.gov.my/i/?sort=1&p=immunization&currentPage...

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South African Minister admits HIV linked to AIDS.

Contributed by Ron Hughes. Tuesday, 14 October 2008.

After a decade of denial, ...

gaynt.e-p.net.au/index2.php?option=com_content&do_pdf=1&id...

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Dangers linked to AIDS arise from the inability of the body to fight off other infections and diseases.

www.sacschool.com/uploads/files/AIDS%20questionnaire.pdf

------------------------------------------------------------------------------------------------------------------------------------------

AEGiS-UPI: Retroviruses are 'Unique in Biology'

... linked to AIDS. ... HTLV-3 has since been renamed HIV-1, for human immunodeficiency virus.

...
www.aegis.org/NEWS/UPI/1986/UP861201.html

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The origin of HIV and AIDS: An enigma of evolution

SM Katrak - 2006

The virulent HIV-1 has its closest counterpart in SIV of the chimpanzees (SIV-cpz) ....

A pathogenic retrovirus (HTLV-III) linked to AIDS. ...

www.annalsofian.org/article.asp?issn=0972-2327;year..

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AIDS is the later stage of HIV infection, when the body begins losing its ability to ...

www.emedicinehealth.com › home › topics az list

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Op-Ed Contributor - A Case of Chronic Denial - NYTimes.com

21 Oct 2009 ... A Case of Chronic Denial ... XMRV had been discovered in people suffering from chronic fatigue syndrome, a malady whose very existence has ...

www.nytimes.com/2009/10/21/opinion/21johnson.html

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WHO | WHO and HIV/AIDS

The HIV/AIDS Department provides evidence-based, technical support to WHO Member States to help them scale up treatment, care and prevention services as ...

www.who.int › WHO › Programmes and projects › HIV/AIDS

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XMRV/{CFS/ME} : CFS/ME is the later stage of XMRV infection

HIV/AIDS : AIDS is the later stage of HIV infection
HIV/AIDS : AIDS is the later stage of HIV infection
HIV/AIDS : AIDS is the later stage of HIV infection

XMRV/{CFS/ME} : CFS/ME is the later stage of XMRV infection
XMRV/{CFS/ME} : CFS/ME is the later stage of XMRV infection
XMRV/{CFS/ME} : CFS/ME is the later stage of XMRV infection

XMRV-induced Autism Spectrum Disorders (40%)

------------------------------------------------------------------------------------------------------------------------------------------

General Conclusion

------------------------------------------------------------------------------------------------------------------------------------------

XMRV may cause autism during the first three years of human life due to serotonin toxicity as a result of a serotonergic agent in pharmaceuticals causing a potentially life-threatening medical complication, called serotonin syndrome, causing brainstem damage resulting in autism.

Serotonergic agents may more rapidly cause serotonin syndrome in those infected with XMRV, and those serotonergic agents may do so with more serious consequences, also later in life, when those infected with XMRV may unnecessarily and counterproductively receive fluoxetine prescription for treatment of a misdiagnosed depression, resulting in hypotension irreparably becoming hypertension.

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XMRV involvement in autism
XMRV involvement in autism
XMRV involvement in autism

brainstem involvement in autism
brainstem involvement in autism
brainstem involvement in autism

brainstem involvement in serotonin syndrome
brainstem involvement in serotonin syndrome
brainstem involvement in serotonin syndrome

dextromethorphan (cough syrup)
dextromethorphan (cough syrup)
dextromethorphan (cough syrup)

involvement in serotonin syndrome
involvement in serotonin syndrome
involvement in serotonin syndrome

dextromethorphan is a serotonergic agent
dextromethorphan is a serotonergic agent
dextromethorphan is a serotonergic agent

dextromethorphan is a pharmaceutical agent
dextromethorphan is a pharmaceutical agent
dextromethorphan is a pharmaceutical agent

dextromethorphan may cause serotonin syndrome
dextromethorphan may cause serotonin syndrome
dextromethorphan may cause serotonin syndrome

serotonergic agents may cause serotonin syndrome
serotonergic agents may cause serotonin syndrome
serotonergic agents may cause serotonin syndrome

fluoxetine is a serotonergic agent
fluoxetine is a serotonergic agent
fluoxetine is a serotonergic agent

fluoxetine may cause serotonin syndrome
fluoxetine may cause serotonin syndrome
fluoxetine may cause serotonin syndrome

pharmaceutical agents may cause serotonin syndrome
pharmaceutical agents may cause serotonin syndrome
pharmaceutical agents may cause serotonin syndrome

------------------------------------------------------------------------------------------------------------------------------------------

CONCLUSION :

[1]

XMRV + dextromethorphan (cough syrup) => serotonin syndrome => brainstem damage => autism

[2]

XMRV + serotonergic agent (pharmaceutical agent)=> serotonin syndrome => brainstem damage => autism

[3]

XMRV may cause autism during the first three years of human life due to serotonin toxicity as a result of a serotonergic agent in pharmaceuticals causing a potentially life-threatening medical complication, called serotonin syndrome, causing brainstem damage resulting in autism.

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CFS/ME - CFS/ME - CFS/ME - CFS/ME - CFS/ME - CFS/ME

It might take up to ten years
It might take up to ten years
It might take up to ten years
for a person with XMRV to develop CFS/ME.
for a person with XMRV to develop CFS/ME.
for a person with XMRV to develop CFS/ME.

------------------------------------------------------------------------------------------------------------------------------------------

autism - autism - autism - autism - autism - autism -

a cough syrup containing dextromethorphan
a cough syrup containing dextromethorphan
a cough syrup containing dextromethorphan

dextromethorphan
dextromethorphan
dextromethorphan

Dextromethorphan poisoning
Dextromethorphan poisoning
Dextromethorphan poisoning

causes

serotonin syndrome
serotonin syndrome
serotonin syndrome

potentially life-threatening
potentially life-threatening
potentially life-threatening

serotonin toxicity
serotonin toxicity
serotonin toxicity

may be fatal
may be fatal
may be fatal

Serotonin is known to be implicated in autism
Serotonin is known to be implicated in autism
Serotonin is known to be implicated in autism

serotonin levels raised in some autism cases
serotonin levels raised in some autism cases
serotonin levels raised in some autism cases

brainstem involvement in autism
brainstem involvement in autism
brainstem involvement in autism

morphological disorders of the brainstem and cerebellum in autism
morphological disorders of the brainstem and cerebellum in autism
morphological disorders of the brainstem and cerebellum in autism

XMRV in about 40% of ASD children
XMRV in about 40% of ASD children
XMRV in about 40% of ASD children

XMRV-seropositivity in 40% of autism cases
XMRV-seropositivity in 40% of autism cases
XMRV-seropositivity in 40% of autism cases

Serotonin syndrome linked to the brain stem and the spinal cord
Serotonin syndrome linked to the brain stem and the spinal cord
Serotonin syndrome linked to the brain stem and the spinal cord

The brainstem is known to be involved in autism.
The brainstem is known to be involved in autism.
The brainstem is known to be involved in autism.

The brainstem and spinal cord are known to be involved in CFS/ME.
The brainstem and spinal cord are known to be involved in CFS/ME.
The brainstem and spinal cord are known to be involved in CFS/ME.

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Literature

------------------------------------------------------------------------------------------------------------------------------------------

AIDS is the later stage of HIV infection. It can take up to ten years for a person with HIV to develop AIDS. When a person with HIV develops ...

www.fhi.org/NR/rdonlyres/.../YouareSpecial.pdf

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Morphological evidence for brainstem involvement in infantile autism

GR Gaffney - 1988 - Cited by 79

the brainstem structure of autistic patients ...

www.journals.elsevierhealth.com/periodicals/bps/article/.../abstract

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Development of the brainstem and cerebellum in autistic patients.

T Hashimoto - 1995

Studies of magnetic resonance images have revealed morphological disorders of the brainstem and cerebellum in autistic children and adults. ...

www.ncbi.nlm.nih.gov/pubmed/7608030

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Another case of serotonin syndrome

a cough syrup containing dextromethorphan ...

serotonin syndrome caused by ...

www.medicinescomplete.com/mc/stockley/current/x23-3539.htm

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The serotonin syndrome (SS) is a potentially life-threatening drug ... dextromethorphan containing cough syrup...

linkinghub.elsevier.com/retrieve/pii/S016383430500109X

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Serotonin syndrome - MayoClinic.com

Severe serotonin syndrome can be fatal if it isn't treated. ... inhibitors (SNRIs) may result in life-threatening serotonin syndrome. ...

Dextromethorphan poisoning: An evidence-based consensus guideline for out-of-hospital management.

...

www.mayoclinic.com/health/serotonin-syndrome/ds00860

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A fatal case of severe serotonin syndrome accompanied by ...

S Sener - 2005

drugs that increase central serotonin dextromethorphan, ... life-threatening serotonin syndrome and died after ...

tspace.library.utoronto.ca/bitstream/1807/5290/1/cm05027.pdf

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USPharmacist.com > Serotonin Syndrome

MAE Zagaria - 2007

Serotonin syndrome, also referred to as serotonin toxicity, is one such condition that, in some cases, may be fatal. ... several mechanisms that result in excess serotonin, severe, life-threatening serotonin toxicity .... products that may elevate serotonin
levels (e.g., dextromethorphan and St. John's wort).

...

www.uspharmacist.com/content/t/senior_care/c/10209/

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... cases of serotonin syndrome—a life threatening condition—when dextromethorphan ...

linkinghub.elsevier.com/retrieve/pii/S0735675704002499

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Serotonin syndrome is an uncommon but potentially life-threatening condition ... Fatal serotonin syndrome following a combined overdose of moclobemide, ...

www.cjem-online.ca/v4/n2/p98

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Autism: eMedicine Pediatrics: Developmental and Behavioral

Serotonin syndrome. Neurology. Feb 1995;45(2):219-23. ...

emedicine.medscape.com › ... › Medical Topics

------------------------------------------------------------------------------------------------------------------------------------------

Serotonin syndrome

www.cnn.com/HEALTH/.../serotonin-syndrome/DS00860.html

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Some symptoms of serotonin syndrome can mimic those due to an overdose of cocaine, ....

health.nytimes.com › Times Health Guide › s

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KS Reddy - 2005 - Cited by 48

Serotonin is the neurotransmitter implicated in autism [8].

www.biomedcentral.com/1471-2350/6/3

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Researchers tested blood samples from a "small group of children" with autism and found that 40% of them were positive for XMRV, ...

www.huffingtonpost.com/.../is-autism-associated-with_b_316986.html

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There's a discussion of the link between XMRV and autism ... autism and found that 40% of them were positive for XMRV, ...

www.wrongplanet.net/postt110616.html

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higher levels of XMRV in people with Autism ...

www.prohealth.com/library/print.cfm?libid=14977

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I've heard that as many as 40% of ASD kids have XMRV. ...

www.autismweb.com/forum/viewtopic.php?f=4&t=21080

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XMRV in about 40% of ASD children studied. ...

scienceblogs.com/erv/.../xmrv_and_chronic_fatigue_syndr_7.php

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He reports that a small study in Nevada (not published or controlled, apparently) found XMRV in 40% of children with autism. ...

ksjtracker.mit.edu/2009/10/14/virus-goes-viral/

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Links on "Whittemore Peterson Institute" | Facebook

And 40% of autistic children in the study were infected with XMRV.

www.facebook.com/posted.php?id=154801179671&share...

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[Progressive cerebellar atrophy following acute antidepressant ...

Y Fujino - 2000

A 37-year-old woman presented with acute cerebellar atrophy after ...

These clinical and laboratory features suggested that she had serotonin syndrome (SS). ...

www.ncbi.nlm.nih.gov/pubmed/11296369

------------------------------------------------------------------------------------------------------------------------------------------

Did serotonin syndrome permanently ruin my brain?

SS may cause cerebellar degeneration

www.bluelight.ru › ... › Healthy Living › Archive - Healthy Living

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Anxiety-like behavior ...

I YAMADA - 2002

severe serotonin syndrome ...

cerebellum of the neonatal 5,7-DHT-treated rats. ...

sciencelinks.jp › ... › Japanese Journal of Psychopharmacology(2002)

------------------------------------------------------------------------------------------------------------------------------------------

.... The intensity of the symptoms of serotonin syndrome vary over a wide spectrum, and the milder

...

www.enciclopedia.com.pt/articles.php?article_id=939

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The serotonin syndrome is a complex condition

SB Turkel - 2001

The serotonin syndrome results when serotonergic activity increases to abnormally high levels .......

psy.psychiatryonline.org/cgi/reprint/42/3/258.pdf

------------------------------------------------------------------------------------------------------------------------------------------

Sumatriptan in serotonin syndrome

AK Erdemoglu

Serotonin syndrome is supposed to cause by stimulation of 5-HT-1A and 5-HT2 receptors in the brain stem and spinal cord. The serotonin syndrome has been ...

priory.com/psych/seurotosyn.htm

------------------------------------------------------------------------------------------------------------------------------------------

Prevention of the serotonin syndrome in rats by repeated ...

I Lucki - 1982

prevented the serotonin syndrome in response to either. 5-MeDMT or LSD and also reduced 3H-serotonin binding in the brain stem and spinal cord. ...

www.springerlink.com/index/V400187635625353.pdf

------------------------------------------------------------------------------------------------------------------------------------------

We describe a case of severe serotonin syndrome where rigorous laboratory testing confirmed that dextromethorphan was the only serotonergic agent ingested. ...

journals.lww.com/.../Serotonin_Syndrome_in_Dextromethorphan_Ingestion.13.aspx

------------------------------------------------------------------------------------------------------------------------------------------

Prozac (fluoxetine) ...

fluoxetine ... serotonergic agent. ...

www.drugs.com/.../prozac-with-trazodone-1115-648-2228-0.html

------------------------------------------------------------------------------------------------------------------------------------------

coadministration of fluoxetine and buspirone in seven patients. When serotonergic agents are combined, there is a risk of serotonin hyperstimulation, ...

www.theannals.com/cgi/reprint/34/7/871.pdf

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Abnormally high levels of serotonin in those infected with XMRV

------------------------------------------------------------------------------------------------------------------------------------------

General Conclusion

------------------------------------------------------------------------------------------------------------------------------------------

High levels of serotonin have been found in about 40 percent of children with autism, and XMRV has also been found in about 40 percent of children with autism.

High levels of serotonin have also been found in CFS/ME. XMRV has been found in nearly 100 percent of those who had CFS/ME. Logical conclusion should be that XMRV has the potential to not only cause autism in children, but also CFS/ME in both children and adults.

Abnormally high levels of serotonin may be the hallmark of an infection with XMRV.

These abnormally high levels of serotonin may not always be observed, but the potential to easily reach these extremely high levels of serotonin under the influence of an external factor such as a superimposed viral infection or certain types of pharmaceutical agents should be expected to be present in each individual infected with XMRV.

------------------------------------------------------------------------------------------------------------------------------------------

approximately 40% of children with autistic features have a high level of serotonin

approximately 40% of children with autistic features have XMRV-seropositivity

CFS/ME => abnormally high levels of serotonin

40% of children with autism => abnormally high levels of serotonin

------------------------------------------------------------------------------------------------------------------------------------------

Having a strong inclination for hyperserotonemia may be the hallmark of infection with XMRV.
Having a strong inclination for hyperserotonemia may be the hallmark of infection with XMRV.
Having a strong inclination for hyperserotonemia may be the hallmark of infection with XMRV.
Having a strong inclination for hyperserotonemia may be the hallmark of infection with XMRV.
Having a strong inclination for hyperserotonemia may be the hallmark of infection with XMRV.

------------------------------------------------------------------------------------------------------------------------------------------

Literature

------------------------------------------------------------------------------------------------------------------------------------------

The neurology of autism - Google Books Result

Mary Coleman - 2005 - Psychology - 256 pages

A number of studies have confirmed that approximately 40% of children with autistic features have a high level of serotonin in their platelets as measured ...

books.google.com/books?isbn=0195182227...

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12 Oct 2009 ...

Researchers tested blood samples from a "small group of children" with autism and found that 40% of them were positive for XMRV, ...

www.huffingtonpost.com/.../is-autism-associated-with_b_316986.html

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Some patients with CFS have abnormally high levels of serotonin

http://www.umm.edu/patiented/articles/what_causes_chronic_fatigue_syndro...

------------------------------------------------------------------------------------------------------------------------------------------

Although the mechanisms responsible for hyperserotonemia in autistic subjects remain unclear, converging evidence suggests that high 5-HT levels result from ...

www.nature.com/mp/journal/v7/n1/full/4000923a.html

------------------------------------------------------------------------------------------------------------------------------------------

Hyperserotonemia in Autism

hrcak.srce.hr/file/38683

------------------------------------------------------------------------------------------------------------------------------------------

XMRV-seropositivity and hyperserotonemia in autism & CFS/ME

------------------------------------------------------------------------------------------------------------------------------------------

XMRV-seropositivity and hyperserotonemia in nearly 40% of autism and nearly 100% of CFS/ME
XMRV-seropositivity and hyperserotonemia in nearly 40% of autism and nearly 100% of CFS/ME
XMRV-seropositivity and hyperserotonemia in nearly 40% of autism and nearly 100% of CFS/ME

------------------------------------------------------------------------------------------------------------------------------------------

Abnormally high levels of serotonin in those infected with XMRV

Having a strong inclination for hyperserotonemia may be the hallmark of infection with XMRV.

------------------------------------------------------------------------------------------------------------------------------------------

General Conclusion

------------------------------------------------------------------------------------------------------------------------------------------

High levels of serotonin have been found in about 40 percent of children with autism, and XMRV has also been found in about 40 percent of children with autism.

High levels of serotonin have also been found in CFS/ME. XMRV has been found in nearly 100 percent of those who had CFS/ME. Logical conclusion should be that XMRV has the potential to not only cause autism in children, but also CFS/ME in both children and adults.

Abnormally high levels of serotonin may be the hallmark of an infection with XMRV.

These abnormally high levels of serotonin may not always be observed, but the potential to easily reach these extremely high levels of serotonin under the influence of an external factor such as a superimposed viral infection or certain types of pharmaceutical agents should be expected to be present in each individual infected with XMRV.

------------------------------------------------------------------------------------------------------------------------------------------

approximately 40% of children with autistic features have hyperserotonemia

approximately 40% of children with autistic features have XMRV-seropositivity

CFS/ME => hyperserotonemia

nearly 100% of CFS/ME patients have XMRV-seropositivity

------------------------------------------------------------------------------------------------------------------------------------------

Having a strong inclination for hyperserotonemia may be the hallmark of infection with XMRV.

------------------------------------------------------------------------------------------------------------------------------------------

Literature

http://www.psychologytoday.com/blog/complementary-medicine/201001/xmrv-c...

------------------------------------------------------------------------------------------------------------------------------------------

XMRV-induced autism & XMRV-induced CFS/ME

------------------------------------------------------------------------------------------------------------------------------------------

XMRV-induced autism & XMRV-induced CFS/ME

------------------------------------------------------------------------------------------------------------------------------------------

XMRV-induced autism may occur after XMRV infection passed from mother to child (vertical transmission), and with the following five main causes :

[1] XMRV infection
[2] hyperserotonemia
[3] serotonin syndrome
[4] brainstem degeneration + spinal cord degeneration
[5] viral infection (e.g. Epstein-Barr Virus (EBV/HHV-4) infection)

XMRV-induced autism with XMRV infection very early in life.

------------------------------------------------------------------------------------------------------------------------------------------

XMRV-induced CFS/ME may occur after XMRV infection (horizontal transmission), which can happen any time, earlier or later in life, and with the following five main causes :

[1] XMRV infection
[2] hyperserotonemia
[3] serotonin syndrome
[4] brainstem degeneration + spinal cord degeneration
[5] viral infection, e.g. caused by HHV-6A infection and/or Epstein-Barr Virus (EBV/HHV-4) infection

CFS/ME is the later stage of XMRV infection.

------------------------------------------------------------------------------------------------------------------------------------------

XMRV causes CFS/ME , causing PRCA , causing POTS

-----------------------------------------------------------------------------------------------------------------------------------------

Xenotropic MuLV-related virus (XMRV)
Xenotropic MuLV-related virus (XMRV)
Xenotropic MuLV-related virus (XMRV)

chronic fatigue syndrome/myalgic encephalomyelitis
chronic fatigue syndrome/myalgic encephalomyelitis
chronic fatigue syndrome/myalgic encephalomyelitis

Pure red cell aplasia (PRCA) or erythroblastopenia
Pure red cell aplasia (PRCA) or erythroblastopenia
Pure red cell aplasia (PRCA) or erythroblastopenia

pure red cell aplasia (PRCA)
pure red cell aplasia (PRCA)
pure red cell aplasia (PRCA)

Retrovirus-induced red cell aplasia
Retrovirus-induced red cell aplasia
Retrovirus-induced red cell aplasia

Postural orthostatic tachycardia syndrome
Postural orthostatic tachycardia syndrome
Postural orthostatic tachycardia syndrome

POTS
POTS
POTS

the brain anemia type of orthostatic intolerance
the brain anemia type of orthostatic intolerance
the brain anemia type of orthostatic intolerance
the brain anemia type of orthostatic intolerance
the brain anemia type of orthostatic intolerance
the brain anemia type of orthostatic intolerance
the brain anemia type of orthostatic intolerance
the brain anemia type of orthostatic intolerance
the brain anemia type of orthostatic intolerance

------------------------------------------------------------------------------------------------------------------------------------------

General Conclusion

------------------------------------------------------------------------------------------------------------------------------------------

Orthostatic intolerance in CFS/ME is caused by retrovirus-induced pure red cell aplasia, and XMRV should be held responsible for causing it.

Postural orthostatic tachycardia syndrome (POTS) in CFS/ME is caused by retrovirus-induced pure red cell aplasia, and XMRV should be held responsible for causing it.

Orthostatic intolerance in CFS/ME is caused by retrovirus-induced erythroblastopenia, and XMRV should be held responsible for causing it.

Postural orthostatic tachycardia syndrome (POTS) in CFS/ME is caused by retrovirus-induced erythroblastopenia, and XMRV should be held responsible for causing it.

------------------------------------------------------------------------------------------------------------------------------------------

XMRV in CFS/ME
XMRV in CFS/ME
XMRV in CFS/ME

causes

Retrovirus-induced pure red cell aplasia
Retrovirus-induced pure red cell aplasia
Retrovirus-induced pure red cell aplasia

Pure red cell aplasia (PRCA) or erythroblastopenia
Pure red cell aplasia (PRCA) or erythroblastopenia
Pure red cell aplasia (PRCA) or erythroblastopenia

pure red cell aplasia (PRCA)
pure red cell aplasia (PRCA)
pure red cell aplasia (PRCA)

Coombs-negative hemolytic anemia
Coombs-negative hemolytic anemia
Coombs-negative hemolytic anemia

Nonregenerative Immune-Mediated Anemia
Nonregenerative Immune-Mediated Anemia
Nonregenerative Immune-Mediated Anemia

a type of anemia
a type of anemia
a type of anemia

severe anemia
severe anemia
severe anemia

hemolytic anemia
hemolytic anemia
hemolytic anemia

affecting the precursors to red blood cells
affecting the precursors to red blood cells
affecting the precursors to red blood cells

causing
causing
causing

tachycardia, dyspnea, and weakness
tachycardia, dyspnea, and weakness
tachycardia, dyspnea, and weakness

tachycardia, change in mental status
tachycardia, change in mental status
tachycardia, change in mental status

a change in mental status or neurologic dysfunction
a change in mental status or neurologic dysfunction
a change in mental status or neurologic dysfunction

------------------------------------------------------------------------------------------------------------------------------------------

XMRV in CFS/ME
XMRV in CFS/ME
XMRV in CFS/ME

causes

Retrovirus-induced
Retrovirus-induced
Retrovirus-induced

brain anemia
brain anemia
brain anemia

causing :

[1]

fatigue and lethargy
fatigue and lethargy
fatigue and lethargy

and

[2]

increased heart rate (tachycardia)
increased heart rate (tachycardia)
increased heart rate (tachycardia)

orthostatic intolerance
orthostatic intolerance
orthostatic intolerance

after prolonged standing
after prolonged standing
after prolonged standing

following prolonged exercise
following prolonged exercise
following prolonged exercise

following sustained upright activity
following sustained upright activity
following sustained upright activity

exacerbated by prolonged standing or sitting
exacerbated by prolonged standing or sitting
exacerbated by prolonged standing or sitting

Postural orthostatic tachycardia syndrome
Postural orthostatic tachycardia syndrome
Postural orthostatic tachycardia syndrome

POTS
POTS
POTS

the brain anemia type of orthostatic intolerance
the brain anemia type of orthostatic intolerance
the brain anemia type of orthostatic intolerance

------------------------------------------------------------------------------------------------------------------------------------------

Xenotropic MuLV-related virus (XMRV)
Xenotropic MuLV-related virus (XMRV)
Xenotropic MuLV-related virus (XMRV)

gamma-retroviruses such as MuLV
gamma-retroviruses such as MuLV
gamma-retroviruses such as MuLV

murine leukemia virus (MuLV)
murine leukemia virus (MuLV)
murine leukemia virus (MuLV)

Feline leukemia virus (FeLV)
Feline leukemia virus (FeLV)
Feline leukemia virus (FeLV)

pure red-cell aplasia in cats with FeLV
pure red-cell aplasia in cats with FeLV
pure red-cell aplasia in cats with FeLV

these cats may exhibit
these cats may exhibit
these cats may exhibit

exercise intolerance and dyspnea
exercise intolerance and dyspnea
exercise intolerance and dyspnea

Nonregenerative Immune-Mediated Anemia
Nonregenerative Immune-Mediated Anemia
Nonregenerative Immune-Mediated Anemia

------------------------------------------------------------------------------------------------------------------------------------------

Literature

------------------------------------------------------------------------------------------------------------------------------------------

Orthostatic intolerance in 6 degrees head-down tilt and lower body ...

by K Yajima - 1992 - Cited by 3

The same types of orthostatic intolerance were observed and the index value hit high in the brain anemia type of orthostatic intolerance, ...

www.ncbi.nlm.nih.gov/pubmed/11537576

------------------------------------------------------------------------------------------------------------------------------------------

Delayed Orthostatic Intolerance

by DHP Streeten - 1992 - Cited by 82

fatigue, and lethargy of many debilitated patients might be the results of delayed orthostatic intolerance caused by their anemia of chronic disease. ...

archinte.highwire.org/cgi/reprint/152/5/1066.pdf

------------------------------------------------------------------------------------------------------------------------------------------

Postural orthostatic tachycardia syndrome is an under-recognized ...

by A Hoad - 2008 - Cited by 3

19 Sep 2008 ... POTS was defined as symptoms of orthostatic intolerance associated ... We suggest that clinical evaluation of patients with CFS/ME should ...

qjmed.oxfordjournals.org/cgi/content/full/hcn123v1

------------------------------------------------------------------------------------------------------------------------------------------

increased heart rate (tachycardia)

healthlibrary.brighamandwomens.org/Library/.../85,P00078 -

------------------------------------------------------------------------------------------------------------------------------------------

Hemolytic Anemia: eMedicine Hematology

P Schick

27 Apr 2009 ...

Tachycardia, dyspnea, angina, and weakness occur in patients with severe anemia. Cardiac function is sensitive to anoxia. ...

emedicine.medscape.com/article/201066-overview

------------------------------------------------------------------------------------------------------------------------------------------

Symptomatic anemia resulting in tachycardia,

change in mental status, ...

medical-dictionary.thefreedictionary.com/Symptomatic+anemia

------------------------------------------------------------------------------------------------------------------------------------------

Pure red cell aplasia (PRCA) or erythroblastopenia refers to a type of anemia affecting the precursors to red blood cells but not to white blood cells. ...

en.wikipedia.org/wiki/Pure_red_cell_aplasia

------------------------------------------------------------------------------------------------------------------------------------------

Retrovirus-induced feline pure red cell aplasia: the kinetics of ...

by JL Abkowitz - 1987 - Cited by 15

Within 3 weeks of FeLV-C infection, yet 6-42 weeks before anemia, the traction of ... Red-Cell Aplasia, ...

www.ncbi.nlm.nih.gov/pubmed/2821017

------------------------------------------------------------------------------------------------------------------------------------------

Delayed orthostatic hypotension: A frequent cause of orthostatic ...

by CH Gibbons - 2006 - Cited by 45

Patients then stood in the upright position for 5 minutes. ....

many patients who report symptoms of orthostatic intolerance only after prolonged standing. ...

www.neurology.org/cgi/content/full/67/1/28

------------------------------------------------------------------------------------------------------------------------------------------

Thrombocytopenia and altered mental status in an HIV-positive ...

by LG Stead - 2002 - Cited by 3

The diagnosis of TTP should be considered in any patient with a change in mental status or neurologic dysfunction, thrombocytopenia, and hemolytic anemia. ...

linkinghub.elsevier.com/retrieve/pii/S0736467902004377

------------------------------------------------------------------------------------------------------------------------------------------

Coombs negative Hemolytic anemia

pure red cell aplasia

meeting.bloodjournal.org/cgi/content/abstract/104/11/3930

------------------------------------------------------------------------------------------------------------------------------------------

At the end of aplasia, the CD34+ cell count was monitored daily in a morning ...

Coombs negative hemolytic anemia, ...

www.nature.com/bmt/journal/v27/n5/full/1702812a.html

------------------------------------------------------------------------------------------------------------------------------------------

pure red cell aplasia (PRCA)

Coombs-negative hemolytic anemia

neutropenia

doi.wiley.com/10.1111/j.1365-2257.2006.00866.x

------------------------------------------------------------------------------------------------------------------------------------------

Mechanisms of orthostatic intolerance following very prolonged ...

by SJE Lucas - 2008 - Cited by 6

Mechanisms of orthostatic intolerance following very prolonged exercise ....

jap.physiology.org/cgi/content/full/105/1/213

------------------------------------------------------------------------------------------------------------------------------------------

Orthostatic Intolerance in CFS

The symptom of orthostatic intolerance causing limitation of sustained upright activity is ...

exacerbated by prolonged standing or sitting. ...

In CFS, activities such as light walking may be better tolerated than ...

www.mefmaction.net/Default.aspx?TabName...

------------------------------------------------------------------------------------------------------------------------------------------

Exercise intolerance is a condition where the patient is unable to do physical exercise at the level or for the duration that would be expected of someone ...

en.wikipedia.org/wiki/Exercise_intolerance

------------------------------------------------------------------------------------------------------------------------------------------

Feline Leukemia Virus-associated Myelopathy in Cats

-- Carmichael ...

by KP Carmichael - 2002 - Cited by 8

... had a history of weakness, lethargy, abnormal behavior, ...

pure red-cell aplasia in cats with a prorubricyte-tropic FeLV variant broadly ...

www.vetpathology.org/cgi/content/full/39/5/536

------------------------------------------------------------------------------------------------------------------------------------------

Pure Red Cell Aplasia and Nonregenerative Immune-Mediated Anemia ...

The dog had a two-day history of lethargy and anorexia, ...

Pure red cell aplasia (PRCA) is a disorder in which anemia is caused by erythroid hypoplasia or ...

www.vet.uga.edu/VPP/clerk/kraun/index.php

------------------------------------------------------------------------------------------------------------------------------------------

ViralZone: Gammaretrovirus

Type: Murine leukemia virus (MLV). Main: Feline leukemia virus (FeLV) Gibbon ape leukemia virus (GALV) Xenotropic murine leukemia virus-related virus (XMRV) ...

www.expasy.ch/viralzone/all_by_species/67.html

------------------------------------------------------------------------------------------------------------------------------------------

Human Retroviruses (e.g. gamma-retroviruses such as murine leukaemia
virus. (MuLV))... FeLV. ...

xenotropic MuLV-related virus (XMRV), ...

doi.wiley.com/10.1002/9780470741405.ch36

------------------------------------------------------------------------------------------------------------------------------------------

Xenotropic MuLV-related virus (XMRV)

sciencestage.com/.../xenotropic-murine-leukemia-virus-related-virus.html

------------------------------------------------------------------------------------------------------------------------------------------

As mentioned above, superimposed FeLV ...

these cats may exhibit exercise intolerance and dyspnea. ...

www.vspn.net/VSPNsearch/VINLibrary/lv960028.htm

------------------------------------------------------------------------------------------------------------------------------------------

Exercise intolerance is a condition where the patient is unable to do physical ...

the patient may experience unusual breathlessness (dyspnea), muscle pain ...

en.wikipedia.org/wiki/Exercise_intolerance

------------------------------------------------------------------------------------------------------------------------------------------

Autoimmune Hemolytic Anemia

... lethargy, anorexia (lack of appetite), exercise intolerance, dyspnea (difficulty ...

www.cpvh.com › Articles

------------------------------------------------------------------------------------------------------------------------------------------

dyspnea and exercise intolerance in horses

doi.wiley.com/10.1111/j.1740-8261.1994.tb02052.x

------------------------------------------------------------------------------------------------------------------------------------------

Symptoms: Include exercise intolerance, arrhythmias

...... Affected animals are more easily infected with diseases such as FELV ...... Symptoms: Dyspnea, abnormal posture, ...

www.viim.org/therapeutics/VDR_2004a_final.pdf

------------------------------------------------------------------------------------------------------------------------------------------

The feline leukemia virus (FeLV) has been compared to the human AIDS virus because of its effect on the ....

heart rhythms, syncope, and bloodwork suggestive of ...

www.rockymountnc.gov/police/documents/feline.pdf

------------------------------------------------------------------------------------------------------------------------------------------

chronic fatigue syndrome/myalgic encephalomyelitis

jcp.bmjjournals.com › Table of Contents

------------------------------------------------------------------------------------------------------------------------------------------

XMRV : an extremely potent accelerator of serotonin release

XMRV may be the causative agent for the presence of extremely high serotonin levels both in CFS/ME and in the 40% autism subgroup. Therefore, it may very well be extremely counterproductive to use an antidepressant serotonergic pharmaceutical agent in both CFS/ME and the 40% autism subgroup because such a pharmaceutical agent may raise the serotonin levels in CFS/ME and the 40% autism subgroup to even higher levels than before, most possibly inducing an extremely dangerous medical condition called serotonin syndrome, which might subsequently even be misdiagnosed as a case of bipolar disorder or schizophrenia, because serotonin syndrome may present with symptoms also present in bipolar disorder and schizophrenia. Serotonin syndrome may be fatal, and when the patient survives the ordeal, he or she may end up with damage to the brainstem and the spinal cord as a result of it.

XMRV should be characterized as a retroviral agent that under the right circumstances may appear as an extremely potent and dangerous accelerator of serotonin release.

------------------------------------------------------------------------------------------------------------------------------------------

Literature

------------------------------------------------------------------------------------------------------------------------------------------

Prozac - The Invention of the Antidepressant Prozac
Prozac - a neurotransmitter - is the worlds most widely prescribed antidepressant co-invented by Ray Fuller and the Eli Lilly Company.

inventors.about.com/library/weekly/aa980225.htm

------------------------------------------------------------------------------------------------------------------------------------------

Other common side effects of Seroxat and other SSRI anti-depressants include ... SSRIs (selective serotonin reuptake inhibitors) such as Seroxat or Prozac. ...

www.health4youonline.com/newsletter_antidepressant_seroxat_suicid_attemp...

------------------------------------------------------------------------------------------------------------------------------------------

Selective Serotonin Reuptake Accelerators (SSRAs) are a new category of antidepressants used to elevate mood in people who are suffering from depression by ...

www.life-pharmacy.com/antidepressants/ssras.html

------------------------------------------------------------------------------------------------------------------------------------------

Regulation of serotonin release ... Controls Serotonin Release in the Mouse Frontal Cortex ...

jop.sagepub.com/cgi/content/abstract/14/2/100

------------------------------------------------------------------------------------------------------------------------------------------

Waxing and Waning Serotonin and Melatonin in XMRV-induced CFS/ME

Serotonin and Melatonin in CFS/ME

Serotonin is to day, what melatonin is to night. Serotonin is to being wide awake, what melatonin is to being sound asleep. Serotonin is to increased excitability, what melatonin is to numbness. Serotonin is to jumpiness, what melatonin is to numbness. Serotonin is to excitement, what melatonin is to sedation. Serotonin is to agitation, what melatonin is to drowsiness. Serotonin is excessively present in CFS/ME and the 40% autism group : so at first sight,
the seemingly only logical conclusion might have been, that exogenous melatonin is what is needed in CFS/ME and the 40% autism group. However, serotonin is excessively present in CFS/ME and the 40% autism group, and serotonin is being transformed from serotonin into melatonin, under the influence of the absence of light, under the influence of darkness, which is why in CFS/ME and the 40% autism group, not only serotonin, but also melatonin may very well be present in very high quantities, so that the only logical conclusion might be, that there is neither a shortage of serotonin, nor a shortage of melatonin in CFS/ME and the 40% autism group, and that the real problem in both CFS/ME and the 40% autism group is that little devil, that retrovirus called XMRV, that is playing dangerous games, waxing and waning games, with the health of those with CFS/ME and the 40% autism group. As long as XMRV has not been counteracted with the right choice of a highly potent antiretroviral pharmaceutical agent, the only thing what people with CFS/ME and the 40% autism group can do is to give themselves a dark therapy whenever necessary just in order to transform the excess of serotonin into melatonin.

So this serotonin/melatonin dance is the necessary dance with the devil called XMRV. But this dance is not the only thing that this devil called XMRV has in store for those with CFS/ME and the 40% autism group : this waxing and waning dance is just one of the many things that XMRV does to those with CFS/ME and the 40% autism group.

------------------------------------------------------------------------------------------------------------------------------------------

Serotonin is to day,
what
Melatonin is to night,

Serotonin is to being wide awake
what
Melatonin is to being sound asleep

Serotonin is to increased excitability
what
Melatonin is to numbness

Serotonin is to jumpiness
what
Melatonin is to numbness

Serotonin is to excitement
what
Melatonin is to sedation

Serotonin is to agitation
what
Melatonin is to drowsiness

Serotonin is excessively present in CFS/ME and the 40% autism group :
so at first sight,
the seemingly only logical conclusion might have been,
that
exogenous melatonin is
what is needed in CFS/ME and the 40% autism group.

However,
Serotonin is excessively present in CFS/ME and the 40% autism group,
and
Serotonin is being transformed from
Serotonin into melatonin,
under the influence of the absence of light
under the influence of darkness,
which is why
in CFS/ME and the 40% autism group,
not only serotonin, but also melatonin
may very well be present in very high quantities,
so that the only logical conclusion
might be,
that there is neither a shortage of serotonin, nor a shortage of melatonin
in CFS/ME and the 40% autism group,
and that the real problem in both
CFS/ME and the 40% autism group,
is that little devil, that retrovirus called XMRV,
that is playing dangerous games,
waxing and waning games,
with the health of those with CFS/ME and the 40% autism group.

As long as XMRV
has not been counteracted
with the right choice of a highly potent antiretroviral pharmaceutical agent,
the only thing
what people with
CFS/ME and the 40% autism group
can do
is
to give themselves
a dark therapy
whenever necessary
just in order to
transform
the excess of serotonin
into
melatonin.

So this serotonin/melatonin dance is the necessary dance with the devil called XMRV.

But this dance is not the only thing that this devil called XMRV has in store for those with CFS/ME and the 40% autism group : this waxing and waning dance is just one of the many things that XMRV does to those with CFS/ME and the 40% autism group.

------------------------------------------------------------------------------------------------------------------------------------------

Literature

------------------------------------------------------------------------------------------------------------------------------------------

Serotonin - Metabolism - Pharmacorama

Transformation of serotonin into melatonin, which should not be regarded as a degradation pathway because melatonin is also active, is carried out primarily ...

www.pharmacorama.com/en/Sections/Serotonin_2_1.php

------------------------------------------------------------------------------------------------------------------------------------------

Effects of exogenous melatonin on sleep: a meta-analysis.

by A Brzezinski - 2005 - Cited by 102

Exogenous melatonin reportedly induces drowsiness and sleep, and may ameliorate sleep disturbances, including the nocturnal awakenings associated with old ...

www.ncbi.nlm.nih.gov/pubmed/15649737

------------------------------------------------------------------------------------------------------------------------------------------

Melatonin may be an effective treatment for CFS/ME

------------------------------------------------------------------------------------------------------------------------------------------

Influence of melatonin on fatigue severity in patients with chronic fatigue syndrome and late melatonin secretion.

Eur J Neurol. 2006 Jan;13(1):55-60.

The patients took 5 mg of melatonin orally

[...]

Melatonin may be an effective treatment for patients with CFS and late DLMO, especially in those with DLMO later than 22.00 hours.

http://www.ncbi.nlm.nih.gov/pubmed/16420393

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Jacob Teitelbaum, M.D., internist and author of From Fatigued to Fantastic!, researches treatments for Chronic Fatigue Syndrome and fibromyalgia.

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