What makes us happiest in life? Some people may point to fabulous fame and fortune. But hands down, surveys show that friends and family are the real prize. Even though our need to connect is innate, some of us always go home alone. You could have people around you throughout the day or even be in a lifelong marriage, and still experience a deep, pervasive loneliness. Unsurprisingly, isolation can have a serious detrimental effect on one's mental and physical health.