Depression: Beyond Serotonin

What is available to clients as explanation is the very stuff psychologists and psychiatrists talk about. The culture has become both more psychological-minded and more biological-minded. As a result, Addis has heard clients say things like, "My doctor said this is a chemical imbalance, so why are you talking to me about doing pleasurable activities?" He admonishes professionals: "We don't know what our theories mean to individuals. We say 'chemical imbalance.' A patient thinks, 'I'm damned.' Our theories are not neutral."

Which is why Peter Kramer, who prescribes both psychotherapy and drug therapy, ponders, "which is the umbrella concept?" Is the brain a biological organ and psychotherapy another way to influence the brain? This is the view that psychiatry is moving towards. Or is drug therapy an adjunct to psychotherapy? "This is my model," he says. "Medication is one way of helping patients broaden their perspective." In other words, it's a way to restore what makes people most human—our remarkable capacity to adapt to life's ever changing demands.

The Natural History of Depression

  • Likelihood that a person will develop major depression or dysthymia in his/her lifetime: 6.1 percent
  • Likelihood that a person will suffer some depressive symptoms in his/her lifetime: 23.1 percent
  • Average age of first onset of major depression: 25-29
  • Average duration of all depressive episodes: 20 weeks
  • Percent of patients who recover within a year after onset of symptoms: 74 percent
  • Likelihood of a second or more episodes of major depression: 80 percent
  • Likelihood of a second or more episodes of minor depression: 100 percent
  • Median number of major depressive episodes during a patient's lifetime: 4
  • Percent of patients whose depression takes a chronic unremitting course: 12 percent
  • Incidence of depression in women vs. men: 3.62 vs. 1.98 per 1000 per year
  • Female: male ratio of depression incidence in cultures with low rates of alcoholism: 1:1
  • Rank of unipolar major depression in the world league of disabling diseases in 1990: 4
  • Rank of unipolar major depression among disabling diseases in westernized countries: 2
  • Rank of depression among disabling diseases the world over, projected, in 2020: 2
Tags: antidepressant, Art Buchwald, brain, brain death, caldron, chemical imbalance in the brain, depression, dick cavett, gray drizzle, gusts, listening to prozac, melancholy, mental ailment, mental illness, mike wallace, nerve cells, neuroscience, new book titles, peter d kramer, poet laureate, william styron

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