It rhymes with Prozac

What's in a name? For drug companies deciding what a new medicine will becalled, there's a lot riding on the right choice: a successful patent can be worth millions of dollars. But names matter to doctors and patients, too, for a different reason: of the thousands of reported medication errors made each year in this country, fully a fourth can be blamed on look-alike or sound-alike drug names.

The Food and Drug Administration currently relies on a panel of experts to sort through drug-name applications, rejecting those that sound too much like products already on the shelves. But a recent explosion in the number of drug trademarks has made this task all but impossible.

Enter Bruce Lambert, Ph.D., of the University of Illinois at Chicago. Lambert has designed a computer program that identifies medicine mixups waiting to happen--and that does so by anticipating the operation of the human brain.

"Our short-term memory works by breaking down words into smaller chunks'" Lambert explains. "When some of the same chunks occur in two different names, those names are more likely to be confused." Another way we remember a name is to keep its sound uppermost in our minds. Such verbal memory is fleeting, however, so words with similar sounds can easily be substituted for the right one.

Lambert's computer program match" medicine names with others that resemble them in sound or spelling. Above certain threshold of similarity, he's found, mistakes multiply.

The FDA is taking note: it's now using the program on a trial basis, and may soon put it to work on all drug applications.

PHOTO (COLOR): Rymes with Prozac

Tags: brain, bruce lambert, chunks, computer program, drug applications, drug names, food and drug, human brain, medication errors, medicine, Memory, memory works, name, new medicine, photo color, right choice, rymes, short term memory, technology, trial basis, university of illinois at chicago, verbal memory

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