Theoretically, says Childers, such drugs would break the
behavioral-chemical links, the cycle that keeps cocaine addicts craving
the drug. "We so far have only a long-acting agonist. That would still
help clinically, the way methadone does, and those addicted to cocaine
binges or overdoses would be helped. It might give a hard-core crack
addict a way to come off his high slowly and perhaps not have the
terrible withdrawal and craving."
Another pharmacologic approach that is drawing interest and
controversy is the African hallucinogen ibogaine, made from the shrub
Tabernanthe iboga, which grows in Gabon. Anecdotal evidence and a few
animal studies suggest that ibogaine can cure opiate addictions. It's
banned in the U.S., but a white powder made from it is available in
Holland and many American junkies have gone abroad to get it.
Some patients claim it not only stops cravings for long periods
without withdrawal, but also suppresses all desire for any drugs and
generates an emotional confrontation with their own thoughts and
feelings, during which they are inspired to reorganize their
lives.
Scientists at NIDA say there is no evidence that it works, even
over the long haul. Studies at Johns Hopkins have shown that ibogaine
interrupts dopamine release and stimulates other
neurotransmitters.
Still, most experts say the long-term effects reported by some
users probably have more to do with the desire addicts have to kick their
habits and to their expectation that it will work. At Johns Hopkins, Mark
Molliver, M.D., and his team have also found ibogaine kills brain cells
in a part of the brain--the orbital frontal cortex--linked to obsessive
behavior. At present, neuroscientists at the University of Miami have the
go-ahead to test ibogaine at low doses for safety, but not yet on
addicts.
Transformational psychology. The new view of addiction and some new
ideas about treatment have been fed from such unusual sources as
religion, philosophy, and literature. Recent research conducted on abrupt
personality change is a case in point. The investigators, William Miller
and Catherine Baca, M.D., of the University of New Mexico's Center on
Alcoholism, Substance Abuse and Addictions, credit their study of Joan of
Arc, Malcolm X, Alcoholics Anonymous cofounder Bill Wilson, Saint Paul,
Buddha, Kierkegaard, and Dicken's A Christmas Carol for suggesting means
by which some addicts might kick their habits overnight--much the way
Ebenezer Scrooge went from wretched skinflint to kindly benefactor after
a bad dream.
Whether or not their "transformational psychology" research
translates into a practical treatment for addictive behavior, its
publication this year by the American Psychological Association and
presentation at international drug and alcohol research conferences
reflect a shift in thinking about how people become addicted and how they
might get free. Until now, says Miller, behavioral scientists have stuck
to the conviction that real change, if it happens at all, is gradual and
painstaking. Now, says Miller, we know that "relatively sudden and
profound changes can and do occur, at least occasionally." If that
capability could be harnessed, the impact on addiction could be
profound.
Aversion therapy. Toni Farrenkopf uses aversion conditioning to
treat addictions, particularly those involving gambling and sexual
behavior. He's worked with patients for whom a single incident of
voyeurism, or indecent exposure, sometimes at a very early age, was so
arousing that the addiction held for decades.
"What we've learned is that people who are voyeurs and exposers are
addicted to the rush they get from contemplating, planning, and doing the
behavior, not necessarily from sexual release itself. With pedophiles,
other factors drive the addiction. But in all cases, you want to try and
countercondition the behavior."
Aversive therapy works by introducing negative consequences
immediately after the pleasurable experience occurs. One reason that many
people don't become addicted is that they rarely experience the worst
consequences of their behavior soon enough to override the
pleasure.
Farrenkopf uses covert sensitization with imagery. He'll show a
sexual addict arrest scenarios--being handcuffed, jailed, searched--10
seconds after an erotic exposure and do this repeatedly. Or he'll expose
them to a noxious odor or painfully snap a rubber band on a wrist. "I
help the patients experience all of the painful things that happen when
they are caught, or have to confront their families after getting
caught," he says. "It works for many."
In a related therapy for gamblers and others "addicted to thrills,"
Farrenkopf makes them do an inventory of how people are hurt by their
behavior, and visualize how their family would feel if they were killed
or maimed, how humiliating it would be for a professional to be arrested
for drunk driving.
Behavioral shaping. A recent study by NIDA researcher Kenzie
Preston, Ph.D., uses this method to ease inner-city cocaine addicts off
the drug; they get increasing rewards in the form of redeemable vouchers
to encourage abstinence. At the end of his first 12-week trial, nearly
half the subjects had stayed free of coke for at least seven weeks. Among
the rewards purchased with the vouchers: tennis shoes, tires, clothing,
and a lawyer's fee.
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