And Prozac For All..

According to a recent survey, approximately 48 percent of Americans--almost half the population--has experienced some form of dysthymic disorder. And all of them may qualify for Prozac. Robert Millman, M.D., professor of psychiatry and public health at Cornell, sees the irony of it: "There's nobody nonsyndromal. You can give Prozac to anyone you want."

Which is anathema to what medical science is supposed to be about. "We try to convince people there's some specificity to what we do," says Millman. "But this is embarrassing."

And the list doesn't stop there. Simon Sobo, M.D., director of psychiatry at New Milford Hospital, reports that "Prozac has been successfully used for obsessive hair-pulling, panic disorder, eating disorders, and social and other phobias. It has proven useful to people to free themselves from addictive relationships; to dispel doubts about performance; to overcome obstacles that once seemed impossible. I have even added it to my watering can and found geraniums grow better on it."

He's joking, of course, but only about the geraniums. Add obesity, gambling addiction, and PMS to the spectrum of complaints now being helped by Prozac.

BETTER RECEPTION?

If little is known yet of just how effective these drugs are for psychological distress, even less clear is the actual impact they have on those who benefit from them. Are they simply mood brighteners or are they re-regulating systems that are out of balance? Do they actually change personality, making you feel better than normal, or merely fine-tune it? Do people say, "Gee, I feel more myself on this drug" or "Gee, I'm a different person now"?

Some clinicians, such as Larry Siever, M.D., director of the Outpatient Psychiatry Division at Mt. Sinai School of Medicine in New York, offer an opinion between the two: "If you have a staticky, bland picture on your TV set, you can fix the reception by adjusting the tuning and contrast. Or simply change the channel. My understanding of the medications personally is more the former than the latter."

Of course the big fear surrounding the "channel-changing" aspect of the drugs is that society will evolve into a battalion of "happy soldiers." Exhumed by Kramer himself, the specter of Aldous Huxley's soma--Brave New World's fictional drug that anesthetized citizens into a content unawareness--continues to haunt us and cloud the argument surrounding Prozac. Yet to many, the analogy seems false.

"The drugs, if properly used," says Siever, "shouldn't dampen normal signals of anxiety, not even normal depression. It should not snow under in the way that a hypnotic does a person's normal level of arousal or awareness, but should allow all of these signals to emerge more clearly."

And, he continues, extending the argument, "If depression or other symptoms emerge, whether from psychological or social stresses, aren't people entitled to treatment for these conditions, just as they would get if they had an ulcer in relation to the stresses in their lives?"

Siever's example inadvertently reveals yet another controversy surrounding the use of drugs--any drugs--in fighting these disorders: the contention that pharmacology focuses on the individual rather than examining the larger societal problems that lie behind depression and other ills. Epidemiological studies have shown that more people are suffering from major depression than ever before--at ever-younger ages. Prozac, some argue, puts a Band-Aid on individual symptoms rather than addressing why people are seeking help in ever-increasing numbers.

The response of clinicians is to answer the question with a question: Why must one solution preclude any other?

The fundamental error, they argue, is to assume that the use of Prozac as a therapeutic tool equals an interest only in the biological causes of depression (or sub-depression, or just plain old feeling lousy). Those who can prescribe medication are, by profession, at least partly invested in biological solutions. And since Prozac is usually recommended along with some form of psychotherapy, the conclusion that interpersonal relationships are somehow ignored--or that individual brain chemistry is the one and only root being ad-dressed--seems erroneous.

"We're not saying this is the only way to help," insists Trestman. "We're saying, 'This is one way, but of course there are others.' Many more people can be helped by changing the structure of society than through medicine. But we also have the ability apparently to help many more people with medication than before. Now we have to figure out should we? And for whom? And where does it stop?"

OUT OF THE WOODWORK

Other concerns stem from the staggering numbers of people for whom Prozac would prove beneficial. In 1991, this advertisement appeared in New York's Times and Village Voice:

"ARE YOU DEPRESSED? DO YOU SUFFER FROM FATIGUE? INABILITY TO CONCENTRATE? HAVE TROUBLE SLEEPING OR EATING? IF SO, CONTACT..."

The ad was placed to gather subjects for a study of the effectiveness of Prozac in treating dysthymia. The response, ac-cording to researcher Jesse Rosenthal, M.D., director of psychopharmacology at Beth Israel Medical Center in New York, was "literally thousands of phone calls. It was amazing--all these bright, educated, hardworking people just came out of the woodwork. We found a mother lode of nice people who were able to function, but who were quite literally the walking wounded of New York."

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