Memory's highways

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Struggling to recall a phone number or the name of an old acquaintance can be an incredibly frustrating feeling. "I don't know. I just can't think right now," we often sigh.

But University of California psychiatrist Larry Squire begs to differ with you. At such times, he finds, thinking areas of your brain are likely to be working harder than when a memory comes with ease.

For some time now, scientists have suspected that the hippocampus (a small area near the brain's center) is the command post for creating and recalling memories of people, places, and things--so called declarative memory. Now, Squire and a team in San Diego have found that when you engage in active memory searches, the hippocampus also enlists the frontal cortex to track down distant recollections.

What makes their work so, well, memorable is that it is the first to glimpse memory in action in the minds of normal folks. Using PET (positron emission tomography) scans to take snapshots of brain activity by measuring blood flow, the team tracked a variety of memory tasks in 18 healthy adults. Earlier work relied on matching brain-activity patterns with functional problems in brain-damaged persons.

"The results provide clear evidence in humans of selective activation of the hippocampal region in association with memory function," the team reports in the Proceedings of the National Academy of Sciences.

Squire's study is memorable for another important reason: The pictures contradict the long-held belief that language is processed on the left side of the brain. When he jogged people's memories by showing them word fragments and asking them to recall a whole word, the hippocampal region on the right side lit up more than it did on the left side. That suggests the subjects used visual images of words to trigger their memory.

The new application of imaging devices promises to open the floodgates of human memory research. Picture this occurring sometime in the near future--perhaps they'll be used to evaluate our educational efforts.

Tags: brain, brain activity, declarative memory, frontal cortex, hippocampus, language, left side of the brain, Memory, memory function, national academy of sciences, PET scan, proceedings of the national academy, proceedings of the national academy of sciences, s center, visual images

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