Psychosurgery

7:50 A.M. Toby Eagle, the nurse anesthetist, and Steve Derrer, the anesthesiologist, bring Matthew in and transfer him to the CT scanner bed where he will stay, anesthetized, throughout the operation. They gently explain the tubes.

"Matt, I'm going to give you some medicine through the tube," Derrer says. "It'll feel hot for a second," adds Eagle. Matthew whimpers for an instant and then is quiet. Eagle puts a nose and mouth mask quickly over his face. "Just a little oxygen," she fibs to him. It's really nitrous oxide, and in just moments, he is asleep. Derrer has injected a cocktail of drugs through the tube -- Pentothal, fentanyl, flourane. "Have a good rest, Matt," Eagle says gently. He can't hear her.

7:56 A.M. Eagle passes a breathing tube into Matthew's throat, adds more line. The front part of his hair is shaved from his forehead to about halfway back. They leave the rest, including beard and sideburns. "He cares a lot about his hair," says Gerry. "Most young guys do." Matthew's eyes are taped shut now and the supporting part of the stereotactic frame is placed under his head and shoulders, clamped to the bed that supports him and screwed into his skull with four white screws at the temples.

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8:35 A.M. Vince clears everyone out of the room so he can turn on the CT scanner, which hums. The surgeon, Sumio Uematsu, along with the radiologists, neurologists, and technicians, are crammed into the CT monitor room on and off for most of this first hour. At about 9 A.M., Uematsu looks at reconstructed scans that highlight an important landmark: the telltale butterfly-shaped structure of the corpus callosum. From there, it's only about two centimeters back to the cingulum -- the target. He also locates, among the varied shades of white, gray, and black, the cerebral artery he must avoid.

More than 35 scans are done. "It's got to be right, perfect, absolutely right. We need to check and recheck, check and recheck," says Uematsu. He keeps saying this aloud, yet to himself, almost like a prayer or a mantra.

9:30 A.M. A neurologist who has cared for Matthew for many years arrives with a copy of a medical-journal article written by Tom Ballantine, a Massachusetts neurosurgeon who has done more than 600 cingulotomies for chronic pain. In it are detailed photographs of the sites in the brain where Ballantine recommends placing lesions.

Still holding the article, he gazes at Matthew's draped form through the glass. He does not go into the operating room even when this first round of scanning is completed at 10: 15. Instead, he leaves the suite to see Matthew's family. He will come and go often during the day.

10:16 A.M. Physician's assistant Debbie Mandelblatt places a white stretch cap on Matthew's skull, and over the cap a clear, stretchable plastic -- not unlike thick Saran wrap -- and fastens it down like a sausage casing. The wrap holds the scalp skin taut and sterile and isolates the slits the surgeon will cut in it to reach the skull and brain. "We'll make two burr holes, or entries," Uematsu tells onlookers. "The right side first." Two hours and 15 minutes into this operation, the first real surgery is about to happen.

Five separate times the surgical team validates the settings on a mockup before the coordinates are locked down on the stereotactic frame. Now the electrode probe is positioned on every plane: It can be moved in any direction and the target will always be in the center of the probe.

10:30 A.M. Uematsu makes a one-inch cut in the Saran wrap and skull cap, the slices the skin and underlay scalp. He uses a retractor to hold the skin back and stitches it in place. It's quiet in the room as Uematsu picks up a hand drill, and drills the burr hole, beginning slowly and building to a vigorous circular motion with the handle. He drills and drills into the skull. With suction and irrigation, pieces of bone and tissue gush out on the table under Matthew's head, but very little blood. He sleeps peacefully.

10:45 A.M. Drilling Stops. Uematsu uses currettes (tiny, sharp, curved knives) to clean out the hole. The top half of the stereotactic frame is fastened over the hole. There is a faint smell of burning as he electrically seals the covering of the brain, or dura. Now it's time to set the electrode needle into the brain. The necessary apparatus, already locked into the right place, is lifted from the mockup frame and placed over the bottom half of the device affixed to Matthew's skull. The surgeon will not need to make any judgments about where to put it. The probe will go through the holder and stop automatically at the target area.

He selects the right-size probe from the stainless-steel tray held by Gerry Beveringen, and sets it aside. The frame is ready, the coordinates have been checked a dozen times.

"No," he says. "We'll scan again." Another cross check. He will inject air into the brain, take more scans and make sure the frame's positioned for exactly the fight spot. "Then," Uematsu says, "if we are, I put the needle in."

Vince clears the OR for the scans.

11:30 A.M. It has taken 45 minutes and two injections of air to learn that the black dots of air highlighted in the scanning images are right on target. "Better than textbook, better than perfect," Uematsu exclaims for the first of many times this day. "Now. Now we're ready to go."

Tags: bad reputation, belief, brain surgery, dilemma, horizon, human brain, human subjects, lobotomy, mental illness, nam, neurology, philosophers, pretension, psychiatric disorders, psychosurgery, record keeping, safeguards, scientists, strict regulations, successes, surgery, worth the risk, wretched excess

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